5958-14-5 Usage
Description
2-Mercapto-3-phenylamino-3H-quinazolin-4-one, also known as PD168393, is a chemical compound belonging to the quinazoline family. It is recognized as a potent and selective inhibitor of the epidermal growth factor receptor (EGFR), a protein that is often overactive in cancer cells. PD168393 has garnered attention for its potential role in cancer therapy due to its ability to block EGFR signaling, thereby affecting cell proliferation and survival.
Uses
Used in Pharmaceutical Industry:
PD168393 is utilized as an anti-cancer agent targeting various types of cancer, such as lung, breast, and brain tumors. Its application is based on its mechanism of action, which involves binding to the ATP-binding site of the EGFR. This binding leads to the inhibition of downstream signaling pathways that are crucial for cell proliferation and survival, making PD168393 a promising candidate for cancer treatment.
Used in Cancer Research:
In the field of cancer research, PD168393 serves as a valuable tool for studying the role of EGFR in cancer development and progression. Its selective inhibition of EGFR allows researchers to investigate the effects of blocking this receptor on tumor growth and to explore potential therapeutic strategies targeting EGFR signaling pathways.
Check Digit Verification of cas no
The CAS Registry Mumber 5958-14-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,9,5 and 8 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 5958-14:
(6*5)+(5*9)+(4*5)+(3*8)+(2*1)+(1*4)=125
125 % 10 = 5
So 5958-14-5 is a valid CAS Registry Number.
InChI:InChI=1/C14H11N3OS/c18-13-11-8-4-5-9-12(11)15-14(19)17(13)16-10-6-2-1-3-7-10/h1-9,16H,(H,15,19)
5958-14-5Relevant articles and documents
Synthesis and antihypertensive activity of 2-imino-2,3-dihydro-5H-1,3,4-thiadiazolo[2,3-b]quinazolin-5- ones
Liu,Hu
, p. 166 - 171 (2007/10/02)
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Analytical Applications of 3-Anilino-2-Thiotetrahydroquinazole-4-One (ATQ-4-O) I-Spectrophotometric Determination of Palladium(II)
Singh, A. K.,Singh, R. P.,Ralhan, N. K.
, p. 887 - 889 (2007/10/02)
3-Anilino-2-thiotetrahydroquinazole-4-one (ATQ-4-O) is synthesised and use of its Pd(II)-complex in the spectrophotometric determination of metal is explored.Pd(II)-ATQ-4-O complex absorbs maximum at 370(ε 8400) and 380 nm (ε 10700) respectively in 60perc
