59661-86-8

Basic information

• Product Name: 2-Phenylquinoline-4-carboxylicacidchloride
• Synonyms: 4-QUINOLINECARBONYL CHLORIDE,2-PHENYL-
• CAS NO: 59661-86-8
• Molecular Formula: C₁₆H₁₀ClNO
• Molecular Weight: 267.71
• Mol File: 59661-86-8.mol
• Article Data: 36

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Phenylquinoline-4-carboxylicacidchloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Phenylquinoline-4-carboxylicacidchloride(59661-86-8)
• EPA Substance Registry System: 2-Phenylquinoline-4-carboxylicacidchloride(59661-86-8)

Safety Data

• Hazardous Substances Data: 59661-86-8(Hazardous Substances Data)

Usage

General Description

2-Phenylquinoline-4-carboxylic acid chloride is a chemical compound with the molecular formula C16H10ClNO2. It is a derivative of quinoline and is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 2-Phenylquinoline-4-carboxylicacidchloride is a versatile building block in organic chemistry and can be used in the production of a variety of functionalized quinoline derivatives. Its chemical structure contains a phenyl group and a carboxylic acid functionality, making it an important reagent for the synthesis of a wide range of organic compounds. Additionally, 2-Phenylquinoline-4-carboxylic acid chloride is also used in research laboratories as a starting material for the preparation of novel compounds for biological and medicinal applications.

Upstream product

• 132-60-5 cinchophen 
• 98-86-2 acetophenone 
• 91-56-5 indole-2,3-dione 
• 62-53-3 aniline 
• 42366-35-8 hydroxyimino-N-phenylacetamide 

Downstream Products

• 1752-99-4 2-phenyl-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-quinoline-4-carboxamide 
• 121331-01-9 1,2-diphenyl-4-(2-phenyl-quinoline-4-carbonyl)-pyrazolidine-3,5-dione 
• 122542-03-4 2-phenyl-quinoline-4-carboxylic acid-(4-butyl-5-oxo-1,2-diphenyl-2,5-dihydro-1H-pyrazol-3-yl ester) 
• 524-34-5 2-phenyl-quinoline-4-carboxylic acid allyl ester 
• 606-36-0 (2-phenyl-quinoline-4-carbonyl)-carbamic acid ethyl ester 
• 99670-95-8 N-(2-phenyl-quinoline-4-carbonyl)-glycine ethyl ester 
• 137117-06-7 phenyl(2-phenylquinolin-4-yl)methanone 

Relevant articles and documents

Liquid crystalline cholesterol-based ortho-palladated curcumin complexes as multifunctional biomaterials

Mononuclear ortho-palladated complexes containing 2-phenylquinoline ligand functionalized with a chiral entity and a biologically active O,O chelated ligand have been synthesized and fully characterized. The evaluation of the liquid crystalline properties

Phosphorescent, Cyclometalated Cinchophen-Derived Platinum Complexes: Syntheses, Structures, and Electronic Properties

The syntheses of nine new monometallic heteroleptic platinum complexes [Pt(L1-4)(acac)], [Pt(L1)(hmacac/hfacac)], [PtCl(L1)(py)], [Pt(L1)(8-Q)], [Pt(L1)(bpy)](PF6) (where L1 = 2-phenyl-4-ethyl-quinolinecarboxylate; L2/L3 = N-functionalization o

SMALL MOLECULE ENTEROVIRUS INHIBITORS AND USES THEREOF

This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a quinoline (or similar) structure which function as antagonists of androgen receptor activity, and their use as therapeutics for the treatment of cancer (e.g., castration-resistant prostate cancer) and other conditions characterized with androgen receptor activity and/or androgen receptor expression.

Phenylquinoline transient receptor potential vanilloid 1 antagonists for the treatment of pain: Discovery of 1-(2-phenylquinoline-4-carbonyl)-N-(4-(trifluoromethyl)phenyl)pyrrolidine-3-carboxamide

Reported herein is the design, synthesis, and pharmacologic characterization of a class of TRPV1 antagonists constructed on a phenylquinoline platform that evolved from Cinchophen lead. This design composes three sections: a phenylquinoline headgroup attached to an aliphatic carboxamides, which is tethered at a phenyl tail group. Optimization of this design led to the identification of 37, comprising a pyrrolidine linker and a trifluoromethyl–phenyl tail. In the TRPV1 functional assay, using cells expressed hTRPV1, 37 antagonized capsaicin-induced Ca2+ influx, with an IC50 value of 10.2 nM. In the complete mice analgesic model, 37 exhibited better antinociceptive activity than the positive control BCTC in diverse pain models. All of these results suggested that 37 could be considered as a lead candidate for the further development of antinociceptive drugs.