59674-85-0 Usage
General Description
7-Aminoquinazoline-2,4(1H,3H)-dione is a chemical compound that belongs to the class of quinazoline derivatives. It is a heterocyclic compound containing a quinazoline ring system with an amino group at position 7 and carbonyl groups at positions 2 and 4. 7-aMinoquinazoline-2,4(1H,3H)-dione has potential pharmaceutical applications and is being studied for its biological activities, particularly its role as an antitumor agent, as well as its potential as a tyrosine kinase inhibitor. The synthesis and characterization of 7-Aminoquinazoline-2,4(1H,3H)-dione and its derivatives are of interest due to their potential medicinal properties and therapeutic applications. Further research is being conducted to explore its pharmacological properties and potential use in the development of new drugs.
Check Digit Verification of cas no
The CAS Registry Mumber 59674-85-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,9,6,7 and 4 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 59674-85:
(7*5)+(6*9)+(5*6)+(4*7)+(3*4)+(2*8)+(1*5)=180
180 % 10 = 0
So 59674-85-0 is a valid CAS Registry Number.
59674-85-0Relevant articles and documents
Design, synthesis and biological evaluation of 2-aminoquinazolin-4(3H)-one derivatives as potential SARS-CoV-2 and MERS-CoV treatments
Lee, Jun Young,Shin, Young Sup,Jeon, Sangeun,Lee, Se In,Noh, Soojin,Cho, Jung-Eun,Jang, Min Seong,Kim, Seungtaek,Song, Jong Hwan,Kim, Hyoung Rae,Park, Chul Min
supporting information, (2021/03/15)
Despite the rising threat of fatal coronaviruses, there are no general proven effective antivirals to treat them. 2-Aminoquinazolin-4(3H)-one derivatives were newly designed, synthesized, and investigated to show the inhibitory effects on SARS-CoV-2 and MERS-CoV. Among the synthesized derivatives, 7-chloro-2-((3,5-dichlorophenyl)amino)quinazolin-4(3H)-one (9g) and 2-((3,5-dichlorophenyl)amino)-5-hydroxyquinazolin-4 (3H)-one (11e) showed the most potent anti-SARS-CoV-2 activities (IC50 50 50 > 25 μM). In addition, both compounds showed acceptable results in metabolic stabilities, hERG binding affinities, CYP inhibitions, and preliminary PK studies.