619-17-0 Usage
Description
4-Nitroanthranilic acid, also known as 2-amino-5-nitrobenzoic acid, is an organic compound that belongs to the class of aminobenzoic acids. It is characterized by its orange crystalline powder form and exhibits a sweet taste. 4-Nitroanthranilic acid is anthranilic acid with a nitro substituent at the 4th position, which gives it unique chemical properties and potential applications in various industries.
Uses
Used in Pharmaceutical Industry:
4-Nitroanthranilic acid is used as an intermediate in the synthesis of various pharmaceutical compounds, particularly those with potential therapeutic applications. Its unique chemical structure allows it to be a key component in the development of new drugs targeting specific diseases and conditions.
Used in Chemical Synthesis:
In the chemical industry, 4-Nitroanthranilic acid serves as a valuable building block for the synthesis of a wide range of organic compounds. Its reactivity and functional groups make it suitable for use in the production of dyes, pigments, and other specialty chemicals.
Used in Research and Development:
4-Nitroanthranilic acid is utilized as a research compound in various scientific studies, particularly in the fields of organic chemistry, medicinal chemistry, and materials science. Its unique properties and reactivity make it an interesting subject for exploring new reactions, mechanisms, and potential applications.
Used in Analytical Chemistry:
Due to its distinct chemical properties, 4-Nitroanthranilic acid can be employed as a reagent or reference compound in analytical chemistry. It can be used for the detection, identification, or quantification of specific substances in various samples, contributing to the advancement of analytical techniques and methods.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
4-Nitroanthranilic acid is incompatible with acids, acid chlorides, acid anhydrides, chloroformates and strong oxidizing agents.
Fire Hazard
Flash point data for 4-Nitroanthranilic acid are not available; however, 4-Nitroanthranilic acid is probably combustible.
Purification Methods
Crystallise the acid from water, EtOH (m 271o) or aqueous EtOH (m 269o). The acetyl derivative has m 217o (from EtOH), m 222o (from aqueous EtOH). [Chapman & Stephen J Chem Soc 1796 1925, Beilstein 14 II 234, 14 III 975, 14 IV 1087.]
Check Digit Verification of cas no
The CAS Registry Mumber 619-17-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,1 and 9 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 619-17:
(5*6)+(4*1)+(3*9)+(2*1)+(1*7)=70
70 % 10 = 0
So 619-17-0 is a valid CAS Registry Number.
InChI:InChI=1/C7H6N2O4/c8-6-3-4(9(12)13)1-2-5(6)7(10)11/h1-3H,8H2,(H,10,11)
619-17-0Relevant articles and documents
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Garg
, p. 3683 (1962)
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Functionalization of quinazolin-4-ones part 1: Synthesis of novel 7-substituted-2-thioxo quinazolin-4-ones from 4-substituted-2-aminobenzoic acids and PPh3(SCN)2
Heppell, Jacob,Al-Rawi, Jasim
, p. 162 - 174 (2014/02/14)
4-(Nitro, amino, acetylamino)-2-aminobenzoic acid were allowed to react with PPh3(SCN)2 and gave the crossholding 7-nitro, 7-acetylamino- and 7-amino-2-thioxo quinazolin-4-ones respectively. The nature of the substituent at position 4 of the 2-aminobenzoic acids has significant influence on the outcome of the cyclisation reaction with PPh 3(SCN)2. Similarly, the nature of the substituent at position 7 of the 2-substituted quinazolin-4-ones significantly affected the ease with which alkylation reactions could be performed. The alkylation selectivity of the 7- substiuted-2-thioxo quinazolin-4-ones was found to depend on the nature of the alkyl halide and the nature of the substituent at position 2.
Copper-catalyzed direct amination of ortho-functionalized haloarenes with sodium azide as the amino source
Zhao, Haibo,Fu, Hua,Qiao, Renzhong
experimental part, p. 3311 - 3316 (2010/08/05)
A simple copper-catalyzed direct amination of ortho-functionalized haloarenes (2-halobenzoic acid, 2-halobenzamide, and N-(2-bromophenyl)acetamide derivatives) has been developed with use of NaN3 as the amino source in ethanol, and the corresponding ortho-functionalized aromatic amines were synthesized in good to excellent yields. The protocol undergoes one-pot Ullmann-type coupling of ortho-functionalized haloarenes with NaN3 to lead to ortho-functionalized azidoarenes, followed by reduction with ethanol.