99-55-8 Usage
Chemical Properties
Different sources of media describe the Chemical Properties of 99-55-8 differently. You can refer to the following data:
1. yellow powder
2. 5-Nitro-o-toluidine is a yellow, crystalline
solid.
Uses
Different sources of media describe the Uses of 99-55-8 differently. You can refer to the following data:
1. 5-Nitro-o-toluidine is used in the synthesis of numerous dyes.
2. 2-Methyl-5-nitroaniline may be employed as analytical standard for the surfactant mediated transformations (?254nm) of 2,4-dinitrotoluene.
Preparation
2-Methyl-5-nitrobenzenamine?in concentrated sulfuric acid nitration.
Definition
ChEBI: A C-nitro compound in which the nitro compound is meta to the amino group and para to the methyl group of o-toluidine.
Air & Water Reactions
Insoluble in water. 2-Methyl-5-nitroaniline is sensitive to moisture, light, or prolonged exposure to air.
Reactivity Profile
2-Methyl-5-nitroaniline is incompatible with strong oxidizing agents, acids, acid chlorides, acid anhydrides and chloroformates.
Fire Hazard
Flash point data for 2-Methyl-5-nitroaniline are not available; however, 2-Methyl-5-nitroaniline is probably combustible.
Safety Profile
Confirmed carcinogen
with experimental carcinogenic data.
Moderately toxic by ingestion. Mutation data
reported. Decomposes exothermically when
heated to 150℃. When heated to
decomposition it emits toxic fumes of NOx.
See also NITRO COMPOUNDS OF
AROMATIC HYDROCARBONS.
Carcinogenicity
There
are no data available for evaluating carcinogenic risk to
humans. When 5-nitro-o-toluidine was administered in a
dietary feeding study to F344 rats (50 or 100 ppm) and
B6C3F1 mice (1200 or 2300 ppm) of both sexes, hepatocellular
carcinomas were produced in mice but not in rats.
Shipping
UN2660 Nitrotoluidines (mono), Hazard Class:
6.1; Labels: 6.1-Poisonous materials.
Purification Methods
Acetylate the aniline, and the acetyl derivative is crystallised to constant melting point; then hydrolyse it with 70% H2SO4 and the free base is regenerated by treatment with NH3 [Bevan et al. J Chem Soc 4284 1956]. [Beilstein 12 H 844. 12 IV 1807.]
Incompatibilities
Incompatible with oxidizers (chlorates,
nitrates, peroxides, permanganates, perchlorates, chlorine,
bromine, fluorine, etc.); contact may cause fires or explosions.
Keep away from alkaline materials, strong bases,
strong acids, oxoacids, epoxides, acid chlorides; acid anhydrides;
chloroformates.
Check Digit Verification of cas no
The CAS Registry Mumber 99-55-8 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 9 and 9 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 99-55:
(4*9)+(3*9)+(2*5)+(1*5)=78
78 % 10 = 8
So 99-55-8 is a valid CAS Registry Number.
InChI:InChI=1/C7H8N2O2/c1-5-2-3-6(9(10)11)4-7(5)8/h2-4H,8H2,1H3
99-55-8Relevant articles and documents
Preparation and catalytic performance of active metal sintered membrane reactor anchored with Pt atoms
Ren, Xiaoliang,Wang, Shufang,Ding, Xiaoshu,Zhang, Dongsheng,Wang, Yanji
, p. 2848 - 2853 (2021/01/28)
In the chemical industry, reactors are typically designed and filled with supported catalyst particles. However, the intrinsic problems associated with the internal/external diffusion effect and catalyst separation/loss in these traditional reactors can be very challenging to mitigate. To address these issues, herein, an active metal sintered membrane reactor anchored with Pt atoms was successfully developed, and applied into continuous, liquid-phase, hydrogenation processes. The catalyzing reactions transpired on the active sites that were fastened onto the surface of the reactor's microchannels. As a result, the mass transfer at the gas-liquid-solid three-phase was greatly enhanced, and an incredibly high reaction efficiency was obtained. The novel, active reactor demonstrated a superior catalytic performance and stability to nitrobenzene (NB) hydrogenation at 120 °C and 0.5 MPa H2, which enabled an aniline (ANI) yield of 19.28 molANI h-1 L-1. This work opens a new window for the design of high-performance gas-liquid-solid reactor toward multiphase catalytic reactions. This journal is
A polyamine dendritic polymer-copper complex: A reusable catalyst for the additive-free amination of aryl bromides, and iodides
Avudaiappan,Palmurukan,Unnikrishnan,Sreekumar
, p. 1477 - 1484 (2020/02/05)
A porphyrin-initiated amine-functionalized polyepichlorohydrin dendritic polymer (PPECH-Amine) was effectively synthesized, and its water-soluble copper complex (PPECH-Amine-Cu) was developed by treating it with copper acetate. PPECH-Amine and PPECH-Amine-Cu were characterised by different spectroscopic and microscopic techniques. PPECH-Amine-Cu was identified as a reusable catalyst for the amination of bromo- and iodo-benzene derivatives in aqueous media. Due to the presence of residual amino groups in the PPECH-Amine-Cu catalyst, the protocol does not need any additional base additive, as ammonia itself acts as a base and a coupling partner. Due to the good water-soluble nature of this catalyst, it can be easily separated and reused up to six reaction cycles without any loss in its activity.
RAF-DEGRADING CONJUGATE COMPOUNDS
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Paragraph 0209; 0229, (2018/11/22)
The present disclosure provides, inter alia, RAF-Degrading Conjugate Compounds that are useful in the treatment of cancer and other RAF related diseases. Also provided are, pharmaceutical compositions, methods of treatment, and kits comprising a RAF- Degrading Conjugate Compound.