64976-62-1

Basic information

• Product Name: 8-METHYL-5-NITROQUINOLINE)
• Synonyms: 5-Nitro-8-methylquinoline;NSC 59163
• CAS NO: 64976-62-1
• Molecular Formula: C₁₀H₈N₂O₂
• Molecular Weight: 188.18272
• Mol File: 64976-62-1.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 351.7°C at 760 mmHg
• Flash Point: 166.5°C
• Appearance: /
• Density: 1.298g/cm³
• Vapor Pressure: 8.19E-05mmHg at 25°C
• Refractive Index: 1.661
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 8-METHYL-5-NITROQUINOLINE)(CAS DataBase Reference)
• NIST Chemistry Reference: 8-METHYL-5-NITROQUINOLINE)(64976-62-1)
• EPA Substance Registry System: 8-METHYL-5-NITROQUINOLINE)(64976-62-1)

Safety Data

• Hazardous Substances Data: 64976-62-1(Hazardous Substances Data)

Usage

General Description

8-Methyl-5-nitroquinoline is a chemical compound with the formula C10H8N2O2. It is a yellow crystalline solid with a molecular weight of 188.18 g/mol. 8-METHYL-5-NITROQUINOLINE) is commonly used in the synthesis of pharmaceuticals and agrochemicals due to its diverse biological activities. It has been shown to exhibit antitumor, antimalarial, and antimicrobial properties, making it a valuable building block in drug discovery and development. Additionally, it is used as a fluorescent dye in biochemical and cellular imaging studies. The nitro group in the molecule is known to be an important pharmacophore and contributes to its biological activities. Overall, 8-methyl-5-nitroquinoline is an important chemical with potential applications in medicinal and agricultural fields.

InChI:InChI=1/C10H8N2O2/c1-7-4-5-9(12(13)14)8-3-2-6-11-10(7)8/h2-6H,1H3

Upstream product

• 611-32-5 8-methylquinoline 
• 56-81-5 glycerol 
• 99-55-8 2-methyl-5-nitroaniline 
• 107-18-6 allyl alcohol 

Downstream Products

• 50358-40-2 8-methylquinolin-5-ylamine 
• 83848-59-3 5-nitroquinoline-8-carboxylic acid 
• 88474-18-4 5-fluoro-8-methylquinoline 
• 80690-06-8 5-aminoquinoline-8-carboxylic acid 
• 1373436-72-6 N-((5-nitroquinolin-8-yl)methyl)-N-(phenylsulfonyl)benzenesulfonamide 
• 1575701-52-8 4-methyl-N-[(5-nitroquinolin-8-yl)methyl]benzenesulfonamide 
• 1609646-67-4 N-((5-nitroquinolin-8-yl)methyl)-4-(trifluoromethyl)benzenesulfonamide 
• 1609646-84-5 N-((5-nitroquinolin-8-yl)methyl)-4-nitrobenzenesulfonamide 
• 1609646-85-6 N-((5-nitroquinolin-8-yl)methyl)-4-chlorobenzenesulfonamide 
• 1609646-86-7 N-((5-nitroquinolin-8-yl)methyl)-4-methoxybenzenesulfonamide 
• 1609646-87-8 N-((5-nitroquinolin-8-yl)methyl)-2-(trifluoromethyl)benzenesulfonamide 
• 1609646-88-9 N-((5-nitroquinolin-8-yl)methyl)-3-(trifluoromethyl)benzenesulfonamide 
• 1609646-89-0 N-((5-nitroquinolin-8-yl)methyl)-1-phenylmethanesulfonamide 
• 205046-59-9 8-cyano-5-nitroquinoline 

Relevant articles and documents

IMMUNOMODULATORY COMPOUNDS

Disclosed are immunomodulatory compounds, pharmaceutical compositions containing them, and methods of making and using the compounds to treat diseases and disorders characterized by aberrant protein activity that can be targeted by cereblon.

Palladium-Catalyzed C-H Bond Functionalization Reactions Using Phosphate/Sulfonate Hypervalent Iodine Reagents

A new and operationally simple approach for palladium-catalyzed C-H functionalization reactions utilizing an organophosphorus/sulfonate hypervalent iodine reagent as both an oxidant and the source of a functional group has been developed. Through this method, the oxidative phosphorylation-, sulfonation-, and hydroxylation of unactivated benzyl C(sp3)-H bonds, along with the hydroxylation and arylation of aryl C(sp2)-H bonds, are successfully realized under mild conditions and with excellent site-selectivity. The versatile C-OSO2R bond provides a platform for a wide array of subsequent diversification reactions.

From Anilines to Quinolines: Iodide- and Silver-Mediated Aerobic Double C?H Oxidative Annulation–Aromatization

Quinoline synthesis from easily accessible raw materials such as anilines is a valuable and meaningful task. Herein, we communicate an iodide- and silver-mediated C?H/C?H oxidative annulation–aromatization between anilines and allyl alcohols. This protocol provides a direct route to the synthesis of quinoline derivatives from inexpensive commodities. Various kinds of anilines, even heterocyclic anilines, were shown to be workable substrates, generating the corresponding multi-substituted quinolines in good yields.