59762-59-3

Basic information

• Product Name: 2-(1-benzyl-2-oxo-1,2-dihydro-indol-3-ylidene)malononitrile
• Synonyms: 2-(1-benzyl-2-oxo-1,2-dihydro-indol-3-ylidene)malononitrile
• CAS NO: 59762-59-3
• Molecular Weight: 285.305
• Mol File: 59762-59-3.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: 2-(1-benzyl-2-oxo-1,2-dihydro-indol-3-ylidene)malononitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1-benzyl-2-oxo-1,2-dihydro-indol-3-ylidene)malononitrile(59762-59-3)
• EPA Substance Registry System: 2-(1-benzyl-2-oxo-1,2-dihydro-indol-3-ylidene)malononitrile(59762-59-3)

Safety Data

• Hazardous Substances Data: 59762-59-3(Hazardous Substances Data)

Upstream product

• 1217-89-6 1-benzylisatin 
• 109-77-3 malononitrile 
• 7135-32-2 1-benzylindolin-2-one 
• 620-05-3 iodomethylbenzene 
• 100-39-0 benzyl bromide 
• 91-56-5 indole-2,3-dione 
• 92552-73-3 1-benzyl-3-hydroxyindolin-2-one 

Downstream Products

• 1346253-69-7 ethyl 1'-benzyl-5,5-dicyano-2'-oxospiro[cyclopent[2]ene-1,3'-indoline]-2-carboxylate 
• 1613308-96-5 C₄₀H₃₁N₃O₃ 
• 1561872-97-6 2-amino-1′-benzyl-2′,5,10-trioxo-5,10-dihydrospiro[benzo[g]chromene-4,3′-indoline]-3-carbonitrile 
• 1613459-02-1 C₂₇H₂₁N₅O 
• 625367-49-9 C₂₇H₂₁N₅O 
• 1596598-09-2 methyl 1'-benzyl-2,2-dicyano-5-methoxy-4-triphenyl-λ⁵-phosphanylidene-2',3-dioxospiro[cyclopentane-1,3'-indoline]-5-carboxylate 

Relevant articles and documents

Bifunctional Squaramide-Catalyzed Asymmetric [3 + 2] Cyclization of 2-(1-Methyl-2-oxoindolin-3-yl)malononitriles with Unsaturated Pyrazolones to Construct Spirooxindole-Fused Spiropyrazolones

The present paper reports a highly stereoselective synthesis of spirooxindole-fused spiropyrazolones through the asymmetric [3 + 2] cyclization reaction of 2-(1-methyl-2-oxoindolin-3-yl)malononitriles with unsaturated pyrazolones under mild conditions. Wi

'On water' Knoevenagel condensation of isatins with malononitrile

Grinding of isatins with malononitrile in the presence of 1-5 equiv. of water for 15 min at room temperature affords the corresponding (2-oxo-1,2-dihydro-3H-indol-3-ylidene)malononitriles, the Knoevenagel condensation products, in 89-99% yields.

Iron-catalyzed cross-dehydrogenative coupling of indolin-2-ones with active methylenes for direct carbon-carbon double bond formation

The iron-catalyzed cross-dehydrogenative coupling (CDC) of C(sp3)-H/C(sp3)-H bonds to afford olefins by 4H elimination is described. This method employs air (molecular oxygen) as an ideal oxidant, and is performed under mild, ligand-free and base-free conditions. H2O is the only byproduct. Good tolerance of functional groups and high yields have also been achieved. Preliminary mechanistic investigations suggest that the present transformation involves a radical process.

Iron-catalyzed one-pot oxidation/Knoevenagel condensation reaction using air as an oxidant

A green and highly efficient iron-catalyzed one-pot oxidation/Knoevenagel tandem reaction for the synthesis of α, β-unsaturated nitriles from secondary alcohols and malononitrile has been achieved. The reaction performed under mild conditions with air as