7135-32-2

Basic information

• Product Name: 1-benzyl-1,3-dihydro-2H-indol-2-one
• Synonyms: 1-benzyl-1,3-dihydro-2H-indol-2-one;1-Benzyl-2-oxindole, 1-Benzylindolin-2-one
• CAS NO: 7135-32-2
• Molecular Formula: C₁₅H₁₃NO
• Molecular Weight: 223.26982
• Mol File: 7135-32-2.mol
• Article Data: 68

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-benzyl-1,3-dihydro-2H-indol-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-1,3-dihydro-2H-indol-2-one(7135-32-2)
• EPA Substance Registry System: 1-benzyl-1,3-dihydro-2H-indol-2-one(7135-32-2)

Safety Data

• Hazardous Substances Data: 7135-32-2(Hazardous Substances Data)

Upstream product

• 59-48-3 2-oxoindole 
• 100-44-7 benzyl chloride 
• 7135-33-3 1-benzyl-3,3-dichloro-1H-indol-2(3H)-one 
• 855420-57-4 1-benzyl-3,3-dibromoindolin-2-one 
• 85539-64-6 1-Benzyl-1,3,3a,6,7,7a-hexahydro-indol-2-one 
• 84258-41-3 1-Benzyl-7-chloro-1,4,5,6-tetrahydro-indol-2-one 
• 74585-36-7 N-benzyl-o-chloroacetanilide 
• 112482-71-0 N-benzyl-2-diazo-N-phenylacetamide 
• 1217-89-6 1-benzylisatin 
• 38488-66-3 N-Benzyl-2,2,2-trichloro-N-phenyl-acetamide 
• 178809-24-0 (ortho-bromophenylacetyl)benzylamine 
• 111022-42-5 N-benzyl-N-(2-bromophenyl)acetamide 
• 223668-13-1 1-benzyl-3-diazoquinoline-2,4-dione 
• 145593-40-4 N-benzyl-2,2,2-trichloro-N-(2-cyclohex-2-enyl)acetamide 

Downstream Products

• 412017-64-2 1-benzyl-2-oxo-indoline-3-carbaldehyde 
• 6037-73-6 1-benzyl-2,3-dihydro-1H-indole 
• 145326-63-2 1-benzylindol-2-yl trifluoromethanesulfonate 
• 222533-60-0 1-benzyl-3-(3-methylbut-2-enyl)-1,3-dihydroindol-2-one 
• 254428-28-9 1'-benzylspiro[cyclopropane-1,3'-indolin]-2'-one 
• 685089-21-8 1-benzyl-3,3-bis(hydroxymethyl)oxindole 
• 36208-62-5 1,3-dibenzyl-1,3-dihydroindol-2-one 
• 932027-57-1 1-benzyl-2-bromo-1H-indole 
• 932027-60-6 2-(1-benzyl-1H-indol-2-yl)benzaldehyde 
• 799561-66-3 C₄₄H₄₈N₂O₄ 

Relevant articles and documents

A New Radical Based Synthesis of Lactams and Indolones from Dithiocarbonates (Xanthates).

N,N-disubstituted α-(xanthyl)-acetamides with an olefin on one of the substituents undergo cyclisation to a lactam by a radical chain reaction involving transfer of the xanthate group; anilides lead to the corresponding indolones.

New cell cycle checkpoint pathways regulators with 2-Oxo-indoline scaffold as potential anticancer agents: Design, synthesis, biological activities and in silico studies

3-Arylidene-2-oxo-indoline derivatives are at the heart of a wide range of clinically, medicinally and biologically important compounds among the 2-oxo-indolines. A number of 3-arylidene-2-oxo-indolines have been approved for clinical application. Accordi

3-Carboxamide oxindoles as 1,3-C,N-bisnucleophiles for the highly diastereoselective synthesis of CF3-containing spiro-δ-lactam oxindoles featuring acyl at the ortho-position of spiro carbon atom

A simple and efficient strategy has been established for the synthesis of δ-lactam fused oxindoles via the Michael/N-hemiketalization cascade reaction of 3-carboxamide oxindoles and α,β-unsaturated trifluoromethyl ketones. A wide range of structurally novel CF3-containing spiro-δ-lactam oxindoles featuring acyl at the ortho-position of spiro carbon atoms were obtained in moderate to good yields with excellent diastereoselectivities under mild conditions. This work represents the first example of a systematic study of 3-carboxamide oxindoles as 1,3-C,N bisnucleophiles.

Fenton chemistry enables the catalytic oxidative rearrangement of indoles using hydrogen peroxide

Oxidative rearrangement of indoles is an important transformation to yield 2-oxindoles and spirooxindoles, which are present in many pharmaceutical agents and bioactive natural products. Previous oxidation methods show either broad applicability or greenness but rarely achieve both. Reported is the discovery of Fenton chemistry-enabled green catalytic oxidative rearrangement of indoles, which has wide substrate scope (42 examples) and greenness (water as the only stoichiometric byproduct) at the same time. Detailed mechanistic studies revealed that the Fenton chemistry generated hydroxyl radicals that further oxidize bromide to reactive brominating species (RBS: bromine or hypobromous acid). Thisin situgenerated RBS is the real catalyst for the oxidative rearrangement. Importantly, the RBS is generated under neutral conditions, which addresses a long-lasting problem of many haloperoxidase mimics that require a strong acid for the oxidation of bromide with hydrogen peroxide. It is expected that this new catalytic Fenton-halide system will find wide applications in organic synthesis.