59843-58-2

Basic information

• Product Name: 3-(4-CHLOROPHENYL)PYRAZOLE
• Synonyms: 3-(4-CHLOROPHENYL)-1H-PYRAZOLE;3-(4-CHLOROPHENYL)PYRAZOLE;BUTTPARK 15\04-56;TIMTEC-BB SBB003760;3-(4-Chlorophenyl)pyrazole, 99+%;4-(1H-Pyrazol-3-yl)chlorobenzene;1-Chloro-4-(1H-pyrazol-3-yl)benzene;3-(4-chlorophenyl)-2H-pyrazole
• CAS NO: 59843-58-2
• Molecular Formula: C₉H₇ClN₂
• Molecular Weight: 178.62
• Product Categories: Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyrazoles;PyrazolesHeterocyclic Building Blocks
• Mol File: 59843-58-2.mol
• Article Data: 21

Chemical Properties

• Melting Point: 80 °C
• Boiling Point: 154 °C
• Flash Point: 206.9 °C
• Appearance: light yellow to beige-brown crystalline powder
• Density: 1.2454 (rough estimate)
• Vapor Pressure: 3.09E-05mmHg at 25°C
• Refractive Index: 1.5500 (estimate)
• Storage Temp.: 2-8°C
• PKA: 12.80±0.10(Predicted)
• CAS DataBase Reference: 3-(4-CHLOROPHENYL)PYRAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-CHLOROPHENYL)PYRAZOLE(59843-58-2)
• EPA Substance Registry System: 3-(4-CHLOROPHENYL)PYRAZOLE(59843-58-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-39
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• Hazardous Substances Data: 59843-58-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H7ClN2/c10-8-3-1-7(2-4-8)9-5-6-11-12-9/h1-6H,(H,11,12)

Upstream product

• 15724-88-6 trans-1-(4-chlorophenyl)-3-chloroprop-2-en-1-one 
• 98606-78-1 2-bromo-1-(4-chlorophenyl)-3,3-bis(methylthio)prop-2-en-1-one 
• 101681-15-6 2-(4-Chloro-phenyl)-2-dimethylamino-4,4-diethoxy-butyronitrile 
• 135641-68-8 c-4-p-chlorobenzoyloxy-3-p-chlorophenyl-r-3-methoxycarbonyl-4,5-dihydro-3H-pyrazole 
• 56856-73-6 3-(4-chlorophenyl)-3-ketopropionaldehyde 
• 1072-63-5 1-vinylimidazole 
• 104-88-1 4-chlorobenzaldehyde 
• 22959-34-8 1-(4-chlorophenyl)-2-propyn-1-one 
• 95826-96-3 (E)-1-(4-chlorophenyl)-2-buten-1-one 
• 7575-74-8 p-chloroacetophenone semicarbazone 
• 68-12-2 N,N-dimethyl-formamide 
• 99-91-2 para-chloroacetophenone 
• 15190-08-6 α-(N,N-dimethylamino)-α-(p-chlorophenyl)acetonitrile 
• 637-87-6 1-Chloro-4-iodobenzene 

Downstream Products

• 928299-83-6 3,4-dibromo-5-p-chlorophenyl-1H-pyrazole 
• 18099-21-3 4-chloro-3-(4-chlorophenyl)-1H-pyrazole 
• 17978-27-7 3-p-chlorophenyl-4-bromo-1H-pyrazole 
• 59843-59-3 2-[3-(4-chloro-phenyl)-pyrazol-1-yl]-N,N-dimethyl-propionamide 
• 59843-60-6 2-[5-(4-chloro-phenyl)-pyrazol-1-yl]-N,N-dimethyl-propionamide 
• 156467-08-2 {(η6-p-cymene)RuCl2(3-(4'-chlorophenyl)pyrazole)} 
• 1173291-34-3 1-(2-bromo-6-methoxy-7-methyl-7H-indeno[2,1-c]quinolin-7-yloxy)-3-[3-(4-chloro-phenyl)-pyrazol-1-yl]-propan-2-ol 
• 1335210-58-6 6-chloro-3,4-diphenylpyrazolo[5,1-a]isoquinoline 
• 1383377-60-3 4-bromo-3-(4-chlorophenyl)-1-methyl-1H-pyrazole 

Relevant articles and documents

Preparation method of pyrazole derivative (by machine translation)

The preparation method comprises the following steps: mixing an alkyne propyl alcohol derivative, a halogen source, an acid and a solvent, heating and reacting, and reacting to Meyer - Schuster generate the pyrazole derivative. Compared with the prior art, the preparation method disclosed by the invention has 91% the advantages of maximum yield, simple operation, mild conditions, high conversion rate, few byproducts and the like, and provides a brand-new synthetic method for construction of pyrazole compounds. (by machine translation)

Silver-Mediated [3 + 2] Cycloaddition of Alkynes and N-Isocyanoiminotriphenylphosphorane: Access to Monosubstituted Pyrazoles

A silver-mediated [3 + 2] cycloaddition of "CNN" and "C≡C" for constructing pyrazoles has been described. The "CNN" building block used is N-isocyanoiminotriphenylphosphorane, which is a stable, safe, easy-to-handle, and odorless solid isocyanide. The reaction is characterized by its mild conditions, broad substrate scope, and excellent functional group tolerance.

Transition Metal, Azide, and Oxidant-Free Homo- and Heterocoupling of Ambiphilic Tosylhydrazones to the Regioselective Triazoles and Pyrazoles

With N-tosylhydrazone as an ambiphilic reagent, an unprecedented cyclization reaction of two identical or different tosylhydrazones has been developed to access various 4,5-disubstituted-2H-triazoles under transition metal, azide, and oxidant-free conditi