600-37-3

Basic information

• Product Name: DL -ALPHA-HYDROXYISOVALERIC ACID
• Synonyms: DL -ALPHA-HYDROXYISOVALERIC ACID
• CAS NO: 600-37-3
• Molecular Formula: C₅H₁₀O₃
• Molecular Weight: 118.1311
• EINECS: 209-994-2
• Mol File: 600-37-3.mol
• Article Data: 17

Chemical Properties

• Melting Point: 82-84℃
• Appearance: /
• CAS DataBase Reference: DL -ALPHA-HYDROXYISOVALERIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: DL -ALPHA-HYDROXYISOVALERIC ACID(600-37-3)
• EPA Substance Registry System: DL -ALPHA-HYDROXYISOVALERIC ACID(600-37-3)

Safety Data

• Hazardous Substances Data: 600-37-3(Hazardous Substances Data)

Usage

Purification Methods

Crystallise the acid from ether/pentane. [Beilstein 3 IV 618.] IRRITANT.

InChI:InChI=1/C5H10O3/c1-3(2)4(6)5(7)8/h3-4,6H,1-2H3,(H,7,8)

Upstream product

• 921-08-4 2-chloro-3-methylbutanoic acid 
• 15344-34-0 2-hydroxy-3-methylbutanenitrile 
• 10323-40-7 2-bromoisovaleric acid 
• 759-05-7 3-methyl-2-ketobutanoic acid 
• 26464-31-3 α-iodo-isovaleric acid 
• 56-23-5 tetrachloromethane 
• 18556-89-3 3-methyl-2-oxobutanal 
• 89364-61-4 2,N-dibromo-3-methyl-butyramide 
• 28120-16-3 2-aminooxy-3-methyl-butyric acid 
• 2507-77-9 α-ketoisovalerate 
• 88246-66-6 1,1-bis(trimethylsilyloxy)-3-methyl-1-butene 
• 76792-22-8 (R)-2-bromoisovaleric acid 
• 101-83-7 N-cyclohexyl-cyclohexanamine 
• 7647-01-0 hydrogenchloride 

Downstream Products

• 759-05-7 3-methyl-2-ketobutanoic acid 
• 78-84-2 isobutyraldehyde 
• 17407-56-6 (R)-2-Hydroxy-3-methylbutyric acid 
• 54639-27-9 N-phenyl-2-hydroxy-3-methyl-butanamide 
• 93896-26-5 DL-2-Hydroxy-isovaleryl-glycin-benzylamid 
• 106299-14-3 O-Z-DL-α-Hydroxy-isovaleriansaeure 
• 2528-17-8 α-hydroxy-isovaleric acid t-butyl ester 
• 2441-07-8 (+/-)-2-hydroxy-3-methylbutyric acid benzyl ester 
• 17417-00-4 methyl 2-hydroxy-3-methylbutanoate 
• 83490-55-5 N-Benzyl-2-hydroxy-3-methylbutyrohydroxamsaeure 
• 83490-54-4 N-Ethyl-2-hydroxy-3-methylbutyrohydroxamsaeure 
• 78-83-1 2-methyl-propan-1-ol 
• 124-38-9 carbon dioxide 
• 31321-65-0 2-Hydroxy-3-methyl-butyric acid 2-(4-bromo-phenyl)-2-oxo-ethyl ester 

Relevant articles and documents

2-Bromo-6-isocyanopyridine as a Universal Convertible Isocyanide for Multicomponent Chemistry

The development of 2-isocyanopyridines as novel convertible isocyanides for multicomponent chemistry is reported. Comparison of 12 representatives of this class revealed 2-bromo-6-isocyanopyridine as the optimal reagent in terms of stability and synthetic efficiency. It combines sufficient nucleophilicity with good leaving group capacity of the resulting amide moiety under both basic and acidic conditions. To demonstrate the practical utility of this reagent, an efficient two-step synthesis of the potent opioid carfentanil is presented.

A stable, convertible isonitrile as a formic acid carbanion [ -COOH] equivalent and its application in multicomponent reactions

The application of 2-(2,2-dimethoxyethyl) phenyl isonitrile in Ugi, Passerini, and Ugi-Smiles reactions is described. The simple transformation to highly activated indolyl amides allows functional-group conversion of the isonitrile moiety into a variety of carboxylic acid derivatives, overall acting as a neutral, nucleophilic COOH equivalent. Georg Thieme Verlag Stuttgart.

PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE 2-HALOGENO- CARBOXYLIC ACIDS

The invention provides processes for producing efficiently optically active 2-halogenocarboxylic acids useful in the preparation of drugs or the like and salts thereof with amines. Specifically, an optically active 2-halogenocarboxylic acid is produced by halogenating an optically active amino acid in water in the presence of a hydrophobic organic solvent and nitrous acid with the configuration retained and with the racemization inhibited through the removal of 2-hydroxy- bromocarboxylic acid formed as a by-product; the obtained optically active 2-halogenocarboxylic acid is transferred to an aqueous phase by converting it into a salt thereof with a base, followed by the removal of the organic phase; and the optically active 2-halogenocarboxylic acid is transferred again to an organic solvent phase, followed by the removal of the aqueous phase, whereby an optically active 2-halogenocarboxylic acid is obtained through the removal of a halogen component. Further, a high-quality salt of an optically active 2-halogenocarboxylic acid with an amine can be obtained by a crystallization method wherein the amine is added over the period of 1/2 hour or longer either continuously or in portions and/or wherein the crystallization solvent consists of a hydrophobic organic solvent and a hydrophilic organic solvent.