600178-11-8Relevant articles and documents
Structure-based design and synthesis of novel potent Na+,K +-ATPase inhibitors derived from a 5α,14α-androstane scaffold as positive inotropic compounds
De Munari, Sergio,Cerri, Alberto,Gobbini, Mauro,Almirante, Nicoletta,Banfi, Leonardo,Carzana, Giulio,Ferrari, Patrizia,Marazzi, Giuseppe,Micheletti, Rosella,Schiavone, Antonio,Sputore, Simona,Torri, Marco,Zappavigna, Maria Pia,Melloni, Piero
, p. 3644 - 3654 (2007/10/03)
The design, synthesis, and biological properties of novel inhibitors of the Na+,K+-ATPase as potential positive inotropic compounds are reported. Following our model of superposition between cassaine and digitoxigenin, digitalis-like