60035-71-4

Basic information

• Product Name: EINECS 205-158-6
• Synonyms: EINECS 205-158-6;Methane, chloro(p-chlorophenyl)phenyl- (8ci);Nsc 49126
• CAS NO: 60035-71-4
• Molecular Formula: C13H10Cl2
• Molecular Weight: 237.1245
• Mol File: 60035-71-4.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• CAS DataBase Reference: EINECS 205-158-6(CAS DataBase Reference)
• NIST Chemistry Reference: EINECS 205-158-6(60035-71-4)
• EPA Substance Registry System: EINECS 205-158-6(60035-71-4)

Safety Data

• Hazardous Substances Data: 60035-71-4(Hazardous Substances Data)

Upstream product

• 119-56-2 (4-chlorophenyl)phenylmethanol 
• 7647-01-0 hydrogenchloride 
• 71-43-2 benzene 
• 134-85-0 4-chlorobenzophenone 
• 104-88-1 4-chlorobenzaldehyde 
• 831-81-2 4-chlorophenyl(phenyl)methane 
• 123535-85-3 (R)-(4-chlorophenyl)phenylmethanol 

Downstream Products

• 101573-69-7 4-((4-chlorophenyl)(phenyl)methyl)morpholine 
• 346451-15-8 1,4-bis-(4-chloro-benzhydryl)-piperazine 
• 110145-65-8 4-(4-chloro-benzhydryloxy)-1-methyl-piperidine 
• 95698-58-1 2-{4-[2-(4-chloro-benzhydryloxy)-ethyl]-piperazin-1-yl}-ethanol 
• 97572-82-2 1,4-bis-[2-(4-chloro-benzhydryloxy)-ethyl]-piperazine 
• 54784-27-9 (4-chloro-benzhydryl)-(2-hydroxy-ethyl)-dimethyl-ammonium; chloride 
• 102475-88-7 4-[2-(4-chloro-benzhydryloxy)-ethyl]-piperazine-1-carboxylic acid ethyl ester 
• 30909-42-3 (4-chloro-benzhydryl)-bis-(2-hydroxy-ethyl)-amine 
• 60035-82-7 (4-chlorophenyl)(phenyl)methanethiol 
• 103645-43-8 4-(4-chloro-benzhydryloxy)-1,2,2,6-tetramethyl-piperidine 
• 7364-23-0 1-chloro-4-(methoxy(phenyl)methyl)benzene 
• 28760-95-4 p-Chlorophenylphenylmethyl radical 
• 57298-79-0 4-chlorobenzhydrylium ion 

Relevant articles and documents

Visible Light-Catalyzed Benzylic C-H Bond Chlorination by a Combination of Organic Dye (Acr+-Mes) and N-Chlorosuccinimide

By combining "N-chlorosuccinimide (NCS)"as the safe chlorine source with "Acr+-Mes"as the photocatalyst, we successfully achieved benzylic C-H bond chlorination under visible light irradiation. Furthermore, benzylic chlorides could be converted to benzylic ethers smoothly in a one-pot manner by adding sodium methoxide. This mild and scalable chlorination method worked effectively for diverse toluene derivatives, especially for electron-deficient substrates. Careful mechanistic studies supported that NCS provided a hydrogen abstractor "N-centered succinimidyl radical,"which was responsible for the cleavage of the benzylic C-H bond, relying on the reducing ability of Acr?-Mes.

Synthesis and cytotoxicity studies of novel benzhydrylpiperazine carboxamide and thioamide derivatives

Synthesis and cytotoxic activities of 32 benzhydrylpiperazine derivatives with carboxamide and thioamide moieties were reported. In vitro cytotoxic activities of compounds were screened against hepatocellular (HUH-7), breast (MCF-7) and colorectal (HCT-116) cancer cell lines by sulphorhodamine B assay. In general, 4-chlorobenzhydrylpiperazine derivatives were more cytotoxic than other compounds. In addition, thioamide derivatives (6a-g) have higher growth inhibition than their carboxamide analogs.

Development of small-molecule probes that selectively kill cells induced to express mutant RAS

Synthetic lethal screening is a chemical biology approach to identify small molecules that selectively kill oncogene-expressing cell lines with the goal of identifying pathways that provide specific targets against cancer cells. We performed a high-throughput screen of 303,282 compounds from the National Institutes of Health-Molecular Libraries Small Molecule Repository (NIH-MLSMR) against immortalized BJ fibroblasts expressing HRASG12V followed by a counterscreen of lethal compounds in a series of isogenic cells lacking the HRASG12V oncogene. This effort led to the identification of two novel molecular probes (PubChem CID 3689413, ML162 and CID 49766530, ML210) with nanomolar potencies and 4-23-fold selectivities, which can potentially be used for identifying oncogene-specific pathways and targets in cancer cells.