60143-52-4

Basic information

• Product Name: Threonine, hydrochloride
• CAS NO: 60143-52-4
• Molecular Formula: C4H9NO3.ClH
• Molecular Weight: 155.581
• Mol File: 60143-52-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Threonine, hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Threonine, hydrochloride(60143-52-4)
• EPA Substance Registry System: Threonine, hydrochloride(60143-52-4)

Safety Data

• Hazardous Substances Data: 60143-52-4(Hazardous Substances Data)

Upstream product

• 1447695-69-3 cycloforskamide 
• 1383580-56-0 (2S,4S)-N-((6R,9R,12S,15S,16R,Z)-3-ethylidene-6-(4-hydroxybenzyl)-12-isobutyl-9-isopropyl-16-methyl-2,5,8,11,14-pentaoxo-1-oxa-4,7,10,13-tetraazacyclohexadecan-15-yl)-2,4-dimethylheptanamide 
• 1207348-80-8 micropeptin MZ₇₇₁ 
• 1207348-78-4 micropeptin MZ₁₀₁₉ 
• 1207348-76-2 micropeptin MZ₉₃₉B 
• 1207348-74-0 micropeptin MZ₉₂₅ 
• 1207348-72-8 micropeptin MZ₉₃₉A 
• 1207348-70-6 micropeptin MZ₈₅₉ 
• 914606-75-0 micropeptin MZ₈₄₅ 

Downstream Products

• 80110-55-0 Boc-Tyr-Thr-OH 
• 72-19-5 L-threonine 
• 60538-17-2 (4S,5R)-4-methyl-2-phenyl-4,5-dihydrooxazole-4-carboxylic acid methyl ester 
• 39994-75-7 H-DL-aThr-OMe*HCl 
• 39994-75-7 (+/-) threonine methyl ester hydrochloride 
• 33209-01-7 L-threonine amide hydrochloride 

Relevant articles and documents

Cycloforskamide, a cytotoxic macrocyclic peptide from the sea slug Pleurobranchus forskalii

A macrocylic dodecapeptide, cycloforskamide, was isolated from the sea slug Pleurobranchus forskalii, collected off Ishigaki Island, Japan. Its planar structure was deduced by extensive NMR analyses and was further confirmed by MS/MS fragmentation analyses. Finally, the absolute configuration was determined by total hydrolysis and chiral-phase gas chromatographic analysis. This novel dodecapeptide contains three d-amino acids and three thiazoline heterocycles and exhibits cytotoxicity against murine leukemia P388 cells, with an IC 50 of 5.8 μM.

Micropeptins from an Israeli fishpond water bloom of the cyanobacterium microcystis sp

Seven new natural products, micropeptin MZ845 (1), micropeptin MZ859 (2), micropeptin MZ939A (3), micropeptin MZ925 (4), micropeptin MZ939B (5), micropeptin MZ1019 (6), and micropeptin MZ771 (7), as well as two known micropeptins, cyanopeptolin S (8) and cyanopeptolin SS (9), were isolated from the hydrophilic extract of the cyanobacterium Microcystis sp. that was collected from a fishpond in Kibbutz Ma'ayan Tzvi, Israel, in July 2006. The structures of the pure natural products were elucidated using spectroscopic methods, including UV, 1D and 2D NMR, and MS techniques. The absolute configuration of the chiral centers of the compounds was determined using Marfey's method for HPLC. The inhibitory activity of the compounds was determined for the serine proteases: trypsin, chymotrypsin, thrombin, and elastase. These micropeptins inhibited trypsin with IC50's that varied between 0.6 and 24.2 μM. The SAR of these micropeptins is discussed.