80110-55-0Relevant articles and documents
Structure-activity relationships of peptide T-related pentapeptides
Marastoni,Salvadori,Balboni,Spisani,Gavioli,Traniello,Tomatis
, p. 926 - 928 (2007/10/02)
Fifteen pentapeptide analogs of C-terminal fragment of peptide T, H-Ala-Ser-Thr-Thr-Asn-Tyr-Thr-OH, were prepared and tested for human monocyte chemotaxis. Structure-activity studies suggest that the potent chemotactic activity of H-Thr-Thr-Asn-Tyr-Thr-OH is mediated through the polar properties of the C-terminal carboxyl group and Thr side chains at the critical positions 5 and 8, while the hydroxyl group of N-terminal Thr and its free amino function are not essential requirements for CD4 receptor interactions.
