60375-88-4

Basic information

• Product Name: Benzene, (4,4,4-trifluoro-1-butenyl)-, (E)-
• Synonyms: ((E)-4,4,4-Trifluoro-but-1-enyl)-benzene;4,4,4-trifluoro-1-phenylbut-1-ene;(E)-4,4,4-trifluoro-1-phenylbut-1-ene
• CAS NO: 60375-88-4
• Molecular Formula: C10H9F3
• Molecular Weight: 186.177
• Mol File: 60375-88-4.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: Benzene, (4,4,4-trifluoro-1-butenyl)-, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, (4,4,4-trifluoro-1-butenyl)-, (E)-(60375-88-4)
• EPA Substance Registry System: Benzene, (4,4,4-trifluoro-1-butenyl)-, (E)-(60375-88-4)

Safety Data

• Hazardous Substances Data: 60375-88-4(Hazardous Substances Data)

Upstream product

• 100-42-5 styrene 
• 353-83-3 1,1,1-trifluoro-2-iodoethane 
• 300-57-2 allylbenzene 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 1895006-01-5 dimesityl(trifluoromethyl)sulfonium trifluoromethanesulfonate 
• 4392-24-9 Cinnamyl bromide 
• 4407-36-7 (2E)-3-phenyl-2-propen-1-ol 
• 667-27-6 Ethyl bromodifluoroacetate 
• 683-98-7 methyl bromodifluoroacetate 
• 140-10-3 (E)-3-phenylacrylic acid 
• 536-74-3 phenylacetylene 
• 21087-29-6 trans-3-phenylprop-2-enyl chloride 

Relevant articles and documents

Trifluoroethylation of Alkynes: Synthesis of Allylic-CF3 Compounds by Visible-Light Photocatalysis

Two types of allylic trifluoromethylated compounds were synthesized by reacting alkynes with CF3CH2I using visible-light photocatalysis. Subtle differences in the catalytic system controlled the selectivity of iodotrifluoroethylation

Copper-Catalyzed Oxidative Trifluoromethylation of Terminal Alkenes Using AgCF3

A mild and convenient reaction for oxidative trifluoromethylation of terminal alkenes was developed using in situ generated AgCF3 in the presence of a copper catalyst. The reaction proceeded under an air atmosphere to afford trifluoromethylated allylic compounds in moderate to good yield. This reaction, with no need for highly hygroscopic or corrosive reagents, features not only a simple operation but also various functional group tolerances.

Copper-Catalyzed Trifluoromethylation of Alkyl Bromides

Copper oxidative addition into organohalides is a challenging two-electron process. In contrast, formal oxidative addition of copper to C sp2 carbon-bromine bonds can be accomplished by employing latent silyl radicals under photoredox conditions. This novel paradigm for copper oxidative addition has now been applied to a Cu-catalyzed cross-coupling of C sp3-bromides. Specifically, a copper/photoredox dual catalytic system for the coupling of alkyl bromides with trifluoromethyl groups is presented. This operationally simple and robust protocol successfully converts a variety of alkyl, allyl, benzyl, and heterobenzyl bromides into the corresponding alkyl trifluoromethanes.