60438-50-8

Basic information

• Product Name: 2-METHOXYBENZALACETONE
• Synonyms: 2-METHOXYBENZALACETONE;3-Buten-2-one, 4-(2-methoxyphenyl)-, (3E)-
• CAS NO: 60438-50-8
• Molecular Formula: C₁₁H₁₂O₂
• Molecular Weight: 176.21
• Mol File: 60438-50-8.mol
• Article Data: 45

Chemical Properties

• Boiling Point: 304.1°C at 760 mmHg
• Flash Point: 137.3°C
• Appearance: /
• Density: 1.048g/cm³
• Vapor Pressure: 0.000891mmHg at 25°C
• Refractive Index: 1.549
• CAS DataBase Reference: 2-METHOXYBENZALACETONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHOXYBENZALACETONE(60438-50-8)
• EPA Substance Registry System: 2-METHOXYBENZALACETONE(60438-50-8)

Safety Data

• Hazardous Substances Data: 60438-50-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H12O2/c1-9(12)7-8-10-5-3-4-6-11(10)13-2/h3-8H,1-2H3/b8-7+

Upstream product

• 6051-53-2 (E)-4-(2-hydroxyphenyl)but-3-en-2-one 
• 135-02-4 ortho-anisaldehyde 
• 67-64-1 acetone 
• 6051-53-2 4c-(2-hydroxy-phenyl)-but-3-en-2-one 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 141-97-9 ethyl acetoacetate 
• 1439-36-7 1-triphenylphosphoranylidene-2-propanone 
• 108-22-5 Isopropenyl acetate 
• 1833-53-0 2-(Trimethylsilyloxy)propene 
• 100-66-3 methoxybenzene 
• 1423-60-5 methyl ethynyl ketone 
• 612-16-8 (2-methoxyphenyl)methanol 
• 399513-49-6 (+/-)-(E)-2-[2-(2-methoxy-phenyl)vinyl]-oxirane 

Downstream Products

• 85191-53-3 2-[(E)-2-(2-Methoxy-phenyl)-vinyl]-[1,8]naphthyridine 
• 130028-19-2 (E)-4-(2-Methoxy-phenyl)-but-3-enoic acid methyl ester 
• 55579-56-1 7-chloro-10-hydroxy-3-(2-methoxy-phenyl)-3,4-dihydro-2H,10H-acridine-1,9-dione 
• 55579-77-6 5-(2-Methoxyphenyl)-1,3-cyclohexanedione 
• 144155-06-6 7-Chloro-3-(2-methoxy-phenyl)-3,4-dihydro-2H,10H-acridine-1,9-dione 
• 144155-40-8 7-Chloro-1-[(E)-3-dimethylamino-propylimino]-3-(2-methoxy-phenyl)-1,3,4,10-tetrahydro-2H-acridin-9-one 
• 144128-63-2 7-Chloro-1-[(E)-3-dimethylamino-propylimino]-10-hydroxy-3-(2-methoxy-phenyl)-1,3,4,10-tetrahydro-2H-acridin-9-one 
• 63449-79-6 4-(o-methoxyphenyl)-butan-2-one 
• 5382-23-0 4-chloro-N-methyl-piperidine hydrochloride 
• 1052183-87-5 (4R)-4-(2-methoxy-phenyl)-5-nitro-pentan-2-one 
• 1101846-83-6 (S)-diethyl 2-(1-(2-methoxyphenyl)-3-oxobutyl)malonate 
• 1170965-05-5 (S)-4-(2H-benzotriazol-2-yl)-4-(2-methoxyphenyl)butan-2-one 
• 1170965-31-7 (S)-4-(1H-benzotriazol-1-yl)-4-(2-methoxyphenyl)butan-2-one 

Relevant articles and documents

Design, green synthesis, antioxidant activity screening, and evaluation of protective effect on cerebral ischemia reperfusion injury of novel monoenone monocarbonyl curcumin analogs

Antioxidants with high efficacy and low toxicity have the potential to treat cerebral ischemia reperfusion injury (CIRI). Dienone monocarbonyl curcumin analogs (DMCA) capable of overcoming the instability and pharmacokinetic defects of curcumin possess notable antioxidant activity but are found to be significantly toxic. In this study, a novel skeleton of the monoenone monocarbonyl curcumin analogue sAc possessing reduced toxicity and improved stability was designed on the basis of the DMCA skeleton. Moreover, 32 sAc analogs were obtained by applying a green, simple, and economical synthetic method. Multiple sAc analogs with an antioxidant protective effect in PC12 cells were screened using an H2O2-induced oxidative stress damage model, and quantitative evaluation of structure–activity relationship (QSAR) model with regression coefficient of R2 = 0.918921 was built through random forest algorithm (RF). Among these compounds, the optimally active compound sAc15 elicited a potent protective effect on cell growth of PC12 cells by effectively eliminating ROS generation in response to oxidative stress injury by activating the Nrf2/HO-1 antioxidant signaling pathway. In addition, sAc15 exhibited good protection against CIRI in the mice middle cerebral artery occlusion (MCAO) model. In this paper, we provide a novel class of antioxidants and a potential compound for stroke treatment.

Piperlongumine derivative as well as preparation method and application thereof

The invention discloses a Piperlongumine derivative as well as a preparation method and application thereof. The Piperlongumine derivative has the following structure: the Piperlongumine derivative provided by the invention contains a plurality of Michael addition receptor units, and the novel structure improves the electrophilicity, so that the Piperlongumine derivative has good protein targetingpotential, and the Piperlongumine derivative has a good inhibition effect on thioredoxin reductase; in an antitumor bioactive in-vitro screening experiment, the derivative also has a certain inhibition effect on the growth of tumor cells, and meanwhile, the derivative has an effect of promoting the generation of active oxygen in A549 human lung cancer cells.

One-pot two-step chemoenzymatic deracemization of allylic alcohols using laccases and alcohol dehydrogenases

A series of enantioenriched (hetero)aromatic secondary allylic alcohols has been synthesized through deracemization of the corresponding racemic mixtures combining a non-selective chemoenzymatic oxidation (laccase from Trametes versicolor and oxy-radical TEMPO) and a stereoselective biocatalyzed reduction (lyophilized cells of E. coli overexpressing an alcohol dehydrogenase, ADH). Both steps were performed in aqueous medium under very mild reaction conditions. After optimization, a sequential one-pot two-step protocol was set up, obtaining the corresponding chiral alcohols in moderate to high conversions (48–95%) and enantiomeric excess (65->99% ee). Depending on the ADH stereopreference, both antipodes from these valuable chiral synthons could be prepared, even at preparative scale (119?178 mg), in a straightforward manner.