6048-68-6 Usage
Description
NONAETHYLENE GLYCOL MONOMETHYL ETHER, also known as m-PEG9-alcohol, is a PEG linker containing a hydroxyl group. The hydroxyl group allows for further derivatization or replacement with other reactive functional groups. The hydrophilic PEG spacer enhances solubility in aqueous media, making it a versatile compound for various applications.
Uses
Used in Pharmaceutical Industry:
NONAETHYLENE GLYCOL MONOMETHYL ETHER is used as a pharmaceutical excipient for its ability to improve the solubility and stability of drugs in aqueous solutions. The hydrophilic PEG spacer aids in the formation of drug delivery systems, enhancing the bioavailability and therapeutic efficacy of medications.
Used in Chemical Synthesis:
NONAETHYLENE GLYCOL MONOMETHYL ETHER serves as a versatile building block in chemical synthesis, particularly for the creation of conjugates and prodrugs. The hydroxyl group can be derivatized or replaced with other functional groups, allowing for the development of new compounds with specific properties and applications.
Used in Bioconjugation:
In the field of bioconjugation, NONAETHYLENE GLYCOL MONOMETHYL ETHER is used as a linker molecule to attach biologically active molecules, such as peptides, proteins, or nucleic acids, to other molecules or surfaces. The hydrophilic PEG spacer improves the stability and solubility of the resulting conjugates, while the hydroxyl group provides a reactive site for attachment.
Used in Surface Modification:
NONAETHYLENE GLYCOL MONOMETHYL ETHER is utilized in surface modification to impart specific properties to materials, such as hydrophilicity, biocompatibility, or resistance to protein adsorption. The hydroxyl group can be used to covalently attach the PEG linker to surfaces, while the hydrophilic PEG spacer provides a barrier that prevents non-specific interactions.
Check Digit Verification of cas no
The CAS Registry Mumber 6048-68-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,0,4 and 8 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 6048-68:
(6*6)+(5*0)+(4*4)+(3*8)+(2*6)+(1*8)=96
96 % 10 = 6
So 6048-68-6 is a valid CAS Registry Number.
InChI:InChI=1/C19H40O10/c1-21-4-5-23-8-9-25-12-13-27-16-17-29-19-18-28-15-14-26-11-10-24-7-6-22-3-2-20/h20H,2-19H2,1H3
6048-68-6Relevant articles and documents
Efficient synthesis of small-sized phosphonated dendrons: Potential organic coatings of iron oxide nanoparticles
Garofalo, Antonio,Parat, Audrey,Bordeianu, Catalina,Ghobril, Cynthia,Kueny-Stotz, Marie,Walter, Aurlie,Jouhannaud, Julien,Begin-Colin, Sylvie,Felder-Flesch, Delphine
supporting information, p. 5226 - 5239 (2014/12/10)
We report herein the synthesis of biocompatible small-sized phosphonated monomers and dendrons used as functional coatings of metal oxide nanoparticles, more specifically superparamagnetic iron oxides (SPIOs) for magnetic resonance imaging (MRI) and therapy through hyperthermia. The molecules were engineered to modulate their size, their hydrophilic and/or biocompatible character (poly(amido)amine versus oligoethyleneglycol), the number of anchoring phosphonate groups (monophosphonate versus phosphonic tweezers) and the number of peripheral functional groups for further grafting of dyes or specific vectors. Such a library of hydrophilic phosphonic acids opens new possibilities for the investigation of dendronized nanohybrids as theranostics.
PROCESS FOR PREPARING NONAETHYLENE GLYCOL MONOMETHYL ETHER
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Page/Page column 10-11, (2010/02/14)
The present invention provides a process for preparing nonethylene glycol monomethyl ether.
Calcitonin drug-oligomer conjugates, and uses thereof
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, (2008/06/13)
Calcitonin drug-oligomer conjugates that include a calcitonin drug coupled to an oligomer including a single polyalkylene glycol moiety consisting of between 4 and 10 polyalkylene glycol subunits are disclosed. Pharmaceutical compositions including such conjugates and methods of treating bone disorders by administering such conjugates are also disclosed.