60532-55-0

Basic information

• Product Name: 1-(4-CHLOROPHENYL)-2-(4-TOLUIDINO)-1-ETHANONE
• Synonyms: 1-(4-CHLOROPHENYL)-2-(4-TOLUIDINO)-1-ETHANONE;1-(4-chlorophenyl)-2-[(4-methylphenyl)amino]ethan-1-one
• CAS NO: 60532-55-0
• Molecular Formula: C₁₅H₁₄ClNO
• Molecular Weight: 259.73
• Mol File: 60532-55-0.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(4-CHLOROPHENYL)-2-(4-TOLUIDINO)-1-ETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-CHLOROPHENYL)-2-(4-TOLUIDINO)-1-ETHANONE(60532-55-0)
• EPA Substance Registry System: 1-(4-CHLOROPHENYL)-2-(4-TOLUIDINO)-1-ETHANONE(60532-55-0)

Safety Data

• Hazardous Substances Data: 60532-55-0(Hazardous Substances Data)

Upstream product

• 106-49-0 p-toluidine 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 25917-49-1 1-(4-chlorophenyl)-2-(p-tolylsulfonyloxy)ethanone 
• 115400-12-9 p-chlorophenacyl benzenesulphonate 
• 118985-11-8 p-chlorophenacyl p-chlorobenzenesulphonate 
• 118985-12-9 p-chlorophenacyl m-nitrobenzenesulphonate 
• 99-91-2 para-chloroacetophenone 

Downstream Products

• 146537-28-2 4-(4-Chloro-phenyl)-2-methyl-1-p-tolyl-1H-pyrrole-3-carboxylic acid ethyl ester 
• 155699-83-5 [2-(4-Chloro-phenyl)-2-oxo-ethyl]-p-tolyl-thiocarbamic acid O-phenyl ester 
• 115998-21-5 2-amino-4-(4-chlorophenyl)-1-(p-tolyl)pyrrole-3-carbonitrile 
• 858788-75-7 2-(4-chlorophenyl)-5-methyl-1H-indole 
• 170464-79-6 5-(4-chlorophenyl)-7-(p-tolyl)-3,7-dihydropyrrolo<2,3-d>pyrimidin-4-one 
• 170464-83-2 [5-(4-Chloro-phenyl)-7-p-tolyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-hydrazine 
• 170464-72-9 9-(4-chlorphenyl)-7-(p-tolyl)-7H-pyrrolo<3,2-e>tetrazolo<1,5-c>pyrimidine 
• 1187980-73-9 3-(4-chlorophenyl)-6-methylquinoline 
• 1443130-44-6 (4-chlorophenyl)(1,3-di-p-tolylimidazolidin-4-yl)methanone 
• 1443130-45-7 (4-chlorophenyl)(1-(4-chlorophenyl)-3-p-tolylimidazolidin-4-yl)methanone 
• 1443130-46-8 (4-chlorophenyl)(1-(4-methoxyphenyl)-3-p-tolylimidazolidin-4-yl)methanone 

Relevant articles and documents

New efficient synthesis of 1,4-benzodiazepin-5-ones by catalytic aza-Wittig reaction

1,4-Benzodiazepin-5-ones were synthesized in 71-89% yields from 2-isocyanato-N-(2-oxoalkyl)benzamides via a new catalytic intramolecular aza-Wittig reaction. Starting from easily accessible phthalic anhydride and α-arylamino ketones, the corresponding 2-{[(2-oxoalkyl)amino]carbonyl}benzoic acids underwent sequential formation of the acid azide and Curtis rearrangement to give 2-isocyanato-N-(2-oxoalkyl)benzamides that were reacted directly to give the final 2,4-diaryl-3,4-dihydro-5H-1,4-benzodiazepin-5-ones and 4-aryl-2-tert-butyl-3,4-dihydro-5H-1,4-benzodiazepin-5-ones.

Microwave-assisted, solvent-free Bischler indole synthesis

The solid-state reaction between anilines and phenacyl bromides in the presence of an equimolecular amount of sodium bicarbonate gives N-phenacylanilines. Microwave irradiation of mixtures of these compounds with anilinium bromides at 540 W for 45-60 s provides a mild, general, and environmentally friendly method for the synthesis of 2-arylindoles in 50-56% overall yields. A one-pot variation of the method, involving irradiation of 2:1 mixtures of anilines and phenacyl bromides, was also developed, allowing a simplified experimental procedure and leading to improved yields (52-75%). Georg Thieme Verlag Stuttgart.

PREPARATION OF NEW THIOHYDROXAMIC ACID DERIVATIVES: SYNTHESIS OF SUBSTITUTED 1-HYDROXY-1,2-DIHYDROIMIDAZOLE-2-THIONES

A general method for the synthesis of the title compounds is reported.The N-phenacylarylamines (11), prepared from the corresponding phenacyl bromides (9) and arylamines (10), give the thiono (or dithio) carbamates (12) on treatment with phenoxythionocarb