60561-61-7

Basic information

• Product Name: Benzeneacetamide, a-(phenylamino)-
• CAS NO: 60561-61-7
• Molecular Formula: C14H14N2O
• Molecular Weight: 226.278
• Mol File: 60561-61-7.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Benzeneacetamide, a-(phenylamino)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetamide, a-(phenylamino)-(60561-61-7)
• EPA Substance Registry System: Benzeneacetamide, a-(phenylamino)-(60561-61-7)

Safety Data

• Hazardous Substances Data: 60561-61-7(Hazardous Substances Data)

Upstream product

• 1118-02-1 trimethylsilyl isocyanate 
• 758640-21-0 N-Benzylaniline 
• 538-51-2 benzylidene phenylamine 
• 62-53-3 aniline 
• 100-52-7 benzaldehyde 
• 172095-47-5 (1E,3Z)-1,4-diphenyl-3-trimethylsilyloxy-2-aza-1,3-butadiene 
• 586-96-9 Nitrosobenzene 
• 137910-13-5 1-isopropoxy-4-phenyl-3-t-butyldimethylsilyloxy-2-aza-1,3-butadiene 
• 7664-93-9 sulfuric acid 
• 4553-59-7 2-anilino-2-phenylacetonitrile 
• 4562-19-0 5-amino-3,4-diphenyl-[1,2,3]oxadiazolium; chloride 
• 66003-76-7 Diphenyliodonium triflate 
• 700-63-0 Phenylglycinamid 

Downstream Products

• 75619-97-5 1,2,5-triphenyl-imidazolidin-4-one 
• 3684-12-6 2-phenyl-2-(phenylamino)acetic acid 

Relevant articles and documents

Strecker reactions with hexacyanoferrates as non-toxic cyanide sources

The Strecker reaction is the most widely applied three-component reaction. Although highly useful for the preparation of α-amino nitriles, α-amino acids, hydantoins and numerous related compounds, the need for the application of toxic sources of HCN limits its application in both academic and industrial settings. Here, we present a facile protocol for Strecker reactions using a mixture of potassium ferri- and ferrocyanides as a non-toxic substitute.

Electrophilic amination of 2-azadienes

2-Azadienes 1 bearing a trialkylsilyloxy group on position 3 can be regarded as carboxylic acid synthons. Their cycloadditions with several classes of nitroso compounds have been studied in detail as well as the transformation of the adducts into α-amino acids. The study showed that arylnitroso compounds such as nitrosobenzene reacted with 2-azadienes to give adducts that are potential precursors of α-N-arylamino acids. We have outlined an important limitation to the use of α-chloronitroso compounds. They are not compatible with highly functionalized dienes like 2-azadienes. On the other hand α-cyanonitroso and acylnitroso compounds reacted with azadienes to give adducts which were readily converted into α-amino acid derivatives.

Studies on Mesoionic Compounds. Part 10. Synthesis and Chemical Properties of Mesoionic 1,2,5-Thiadiazolium-3-olates

The preparation of a novel mesoionic heterocycle is described; derivatives of 4-aryl-5-alkyl-1,2,5-thiadiazolium-3-olates (6a-f) are obtained by treatment of α-N-substituted aminophenylacetamides with sulphur monochloride followed by base.