60578-70-3

Basic information

• Product Name: Ethyl 6,7-Dichloro-3,4-dihydro-3-oxo-2-quinoxalinecarboxylate
• Synonyms: Ethyl 6,7-Dichloro-3,4-dihydro-3-oxo-2-quinoxalinecarboxylate ;6,7-Dichloro-2-(ethoxycarbonyl)-3-hydroxyquinoxaline, Ethyl 6,7-dichloro-3,4-dihydro-3-oxoquinoxaline-2-carboxylate;Ethyl 6,7-dichloro-3-hydroxyquinoxaline-2-carboxylate
• CAS NO: 60578-70-3
• Molecular Formula: C11H8Cl2N2O3
• Molecular Weight: 287.101
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 60578-70-3.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Density: 1.58g/cm³
• Refractive Index: 1.654
• CAS DataBase Reference: Ethyl 6,7-Dichloro-3,4-dihydro-3-oxo-2-quinoxalinecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 6,7-Dichloro-3,4-dihydro-3-oxo-2-quinoxalinecarboxylate(60578-70-3)
• EPA Substance Registry System: Ethyl 6,7-Dichloro-3,4-dihydro-3-oxo-2-quinoxalinecarboxylate(60578-70-3)

Safety Data

• Hazardous Substances Data: 60578-70-3(Hazardous Substances Data)

Usage

Uses

A Quinoxaline analogue as NMDA receptor antagonist.

InChI:InChI=1/C11H8Cl2N2O3/c1-2-18-11(17)9-10(16)15-8-4-6(13)5(12)3-7(8)14-9/h3-4H,2H2,1H3,(H,15,16)

Upstream product

• 6306-39-4 1,2-dichloro-4,5-dinitrobenzene 
• 5348-42-5 4,5-Dichloro-1,2-phenylenediamine 
• 609-09-6 Diethyl ketomalonate 
• 685-87-0 Diethyl 2-bromomalonate 

Downstream Products

• 75294-00-7 6,7-Dichloro-3,4-dihydro-3-oxo-2-quinoxaline carboxylic acid 
• 41213-31-4 2,6,7-trichloro-quinoxaline 
• 78470-95-8 6,7-dichloroquinoxaline-2(1H)-one 

Relevant articles and documents

NOVEL QUINOXALINE DERIVATIVES

This invention relates to a novel compound represented by the following Chemical Formula 1, a process for preparing it, and its pharmaceutically approved salt comprising it as an active ingredient. The compound of this invention is GLP 1 receptor regulating low molecular weight compound useful for treatment of metabolic diseases such as diabetes and obesity by regulating the function of glucagon like peptide 1 receptor (GLP 1 receptor) for the disease or disorder carried by GLP 1 since it has the effects on a drop of blood sugar and an improvement of insulin resistance

Small molecule ago-allosteric modulators of the human glucagon-like peptide-1 (hGLP-1) receptor

Following our previous publication describing the biological profiles, we herein describe the structure-activity relationships of a core set of quinoxalines as the hGLP-1 receptor agonists. The most potent and efficacious compounds are 6,7-dichloroquinoxalines bearing an alkyl sulfonyl group at the C-2 position and a secondary alkyl amino group at the C-3 position. These findings serve as a valuable starting point for the discovery of more drug-like small molecule agonists for the hGLP-1 receptor.

Salts of dihalo-3,4-dihydro-3-oxo-2-quinoxaline carboxylic acids and hindered amines

Salts of 6,7-dihalo-3,4-dihydro-3-oxo-2-quinoxaline carboxylic acids and hindered amines, useful in combating influenza A and B.