78470-95-8

Basic information

• Product Name: 2-HYDROXY-6,7-DICHLOROQUINOXALINE
• Synonyms: 2-HYDROXY-6,7-DICHLOROQUINOXALINE;6,7-Dichloro-2-hydroxyquinoxaline;6,7-DICHLORO-2-HYDROXYLQUINOXALINE;6,7-dichloroquinoxalin-2-ol;6,7-dichloroquinoxalin-2(1H)-one
• CAS NO: 78470-95-8
• Molecular Formula: C₈H₄Cl₂N₂O
• Molecular Weight: 215.04
• Mol File: 78470-95-8.mol
• Article Data: 29

Chemical Properties

• Boiling Point: 429.7 °C at 760 mmHg
• Flash Point: 213.6 °C
• Appearance: /
• Density: 1.65 g/cm³
• Vapor Pressure: 5.5E-08mmHg at 25°C
• Refractive Index: 1.706
• CAS DataBase Reference: 2-HYDROXY-6,7-DICHLOROQUINOXALINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXY-6,7-DICHLOROQUINOXALINE(78470-95-8)
• EPA Substance Registry System: 2-HYDROXY-6,7-DICHLOROQUINOXALINE(78470-95-8)

Safety Data

• Hazardous Substances Data: 78470-95-8(Hazardous Substances Data)

Usage

General Description

2-Hydroxy-6,7-dichloroquinoxaline is a chemical compound with the molecular formula C8H4Cl2N2O. It is a chlorinated quinoxaline derivative with a hydroxyl group attached to the aromatic ring. 2-HYDROXY-6,7-DICHLOROQUINOXALINE is used in the synthesis of pharmaceutical drugs and agrochemicals due to its versatile reactivity and biological activities. It has been studied for its potential as an antimicrobial, antiviral, and anticancer agent. Additionally, it has been investigated for its potential use as a corrosion inhibitor and as a precursor in the synthesis of organic compounds. The properties and reactivity of 2-hydroxy-6,7-dichloroquinoxaline make it a valuable building block in organic synthesis and medicinal chemistry.

InChI:InChI=1/C8H4Cl2N2O/c9-4-1-6-7(2-5(4)10)12-8(13)3-11-6/h1-3H,(H,12,13)

Upstream product

• 75294-00-7 6,7-Dichloro-3,4-dihydro-3-oxo-2-quinoxaline carboxylic acid 
• 5348-42-5 4,5-Dichloro-1,2-phenylenediamine 
• 298-12-4 Glyoxilic acid 
• 6295-06-3 butyl glyoxalate 
• 153505-40-9 6,7-Dichloro-3,4-dihydroquinoxalin-2(1H)-one 
• 924-44-7 glyoxylic acid ethyl ester 
• 6306-39-4 1,2-dichloro-4,5-dinitrobenzene 
• 60578-70-3 6,7-dichloro-3-oxo-3,4-dihydro-quinoxaline-2-carboxylic acid ethyl ester 
• 2339-78-8 1,2-dichloro-4-fluoro-5-nitrobenzene 
• 90793-48-9 N-(4,5-Dichlor-2-nitro-phenyl)-glycin-ethylester 

Downstream Products

• 41213-31-4 2,6,7-trichloro-quinoxaline 
• 145369-80-8 1-Phenyl-7,8-dichloro-1,2,4-triazolo [4,3-a]quinoxaline 
• 143007-04-9 1-Phenyl-7,8-dichloro-1,2,4-triazolo[4,3-a]quinoxalin-4(5H)-one 
• 82083-11-2 6,7-Dichlor-1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-2(1H)-chinoxalinon 
• 50616-86-9 6,7-dichloro-1-methyl-3-phenylquinoxalin-2(1H)-one 
• 1503-80-6 6,7-dichloro-3-phenylquinoxalin-2(1H)-one 

Relevant articles and documents

Electro-reductive C-H cyanoalkylation of quinoxalin-2(1H)-ones

Herein, we report a practical electro-reductive protocol for the direct C–H cyanoalkylation of quinoxalin-2(1H)-ones via iminyl radical-mediated ring opening. These mild reactions proceed under metal-, reductant-, and reagent-free conditions to provide synthetically useful cyanoalkylated quinoxalin-2(1H)-ones.

Electro-oxidative C-H alkylation of quinoxalin-2(1: H)-ones with organoboron compounds

Radical cleavage of C-B bonds to accomplish C-H functionalization is synthetically appealing but practically challenging. We report herein a mild electro-oxidative method for efficient C-H alkylation of quinoxalin-2(1H)-ones by means of radical addition reactions of alkyl boronic acids and esters and alkyl trifluoroborates to afford C-C coupled products. This journal is

PIDA-induced oxidative C–N bond coupling of quinoxalinones and azoles

A metal-free promoted direct oxidative C–N bond coupling of quinoxalinones and azoles for the rapid and effective synthesis of potent pharmaceutical important 3-(azol-1-yl)quinoxalin-2-one has been developed. Employing PIDA as the easily available mediator, the desired coupling products were isolated in moderate to excellent yields with a good substrate scope under operational simplicity and mild reaction conditions. Preliminary mechanistic studies suggested that a radical process is likely to be involved in the reaction.