60667-85-8Relevant articles and documents
Ligand-Enabled γ-C(sp3)–H Acetoxylation of Triflyl-Protected Amines
Jia, Wen-Liang,Fernández-Ibá?ez, M. ángeles
supporting information, p. 6088 - 6091 (2018/09/14)
A palladium-catalyzed γ-C(sp3)–H acetoxylation of triflyl-protected amines has been achieved. The use of pyridine or 2-alkoxyquinoline-type ligands is key to the success of this transformation. The reaction is highly diastereoselective and easily scalable, and constitutes a direct approach for the synthesis of γ-hydroxy-α-amino acids and β,γ-dihydroxy amines, which are not readily accessible by other routes.
NMR-based assignment of isoleucine: Vs. allo -isoleucine stereochemistry
Anderson, Zoe J.,Hobson, Christian,Needley, Rebecca,Song, Lijiang,Perryman, Michael S.,Kerby, Paul,Fox, David J.
supporting information, p. 9372 - 9378 (2017/11/22)
A simple 1H and 13C NMR spectrometric analysis is demonstrated that permits differentiation of isoleucine and allo-isoleucine residues by inspection of the chemical shift and coupling constants of the signals associated with the proton and carbon at the α-stereocentre. This is applied to the estimation of epimerisation during metal-free N-arylation and peptide coupling reactions.
Highly tunable arylated cinchona alkaloids as bifunctional catalysts
Quigley, Cormac,Rodriguez-Docampo, Zaida,Connon, Stephen J.
supporting information; scheme or table, p. 1443 - 1445 (2012/03/11)
We report the design and evaluation of a library of chiral bifunctional organocatalysts in which the distance between the catalytically active units can be systematically varied.
