60693-31-4

Basic information

• Product Name: 3-(2,5-DIOXO-PYRROLIDIN-1-YL)-BENZOIC ACID
• Synonyms: 3-(2,5-dioxopyrrolidin-1-yl)benzoic acid(SALTDATA: FREE);Benzoic acid, 3-(2,5-dioxo-1-pyrrolidinyl)-
• CAS NO: 60693-31-4
• Molecular Formula: C₁₁H₉NO₄
• Molecular Weight: 219.2
• Mol File: 60693-31-4.mol
• Article Data: 4

Chemical Properties

• Melting Point: 136-138 °C
• Boiling Point: 564°C at 760 mmHg
• Flash Point: 294.9°C
• Appearance: /
• Density: 1.466g/cm³
• Vapor Pressure: 1.47E-13mmHg at 25°C
• Refractive Index: 1.636
• Storage Temp.: 2-8°C
• PKA: 3.86±0.10(Predicted)
• CAS DataBase Reference: 3-(2,5-DIOXO-PYRROLIDIN-1-YL)-BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2,5-DIOXO-PYRROLIDIN-1-YL)-BENZOIC ACID(60693-31-4)
• EPA Substance Registry System: 3-(2,5-DIOXO-PYRROLIDIN-1-YL)-BENZOIC ACID(60693-31-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 60693-31-4(Hazardous Substances Data)

Usage

General Description

3-(2,5-Dioxo-pyrrolidin-1-yl)-benzoic acid is a chemical compound that consists of a pyrrolidin-1-yl group attached to a benzoic acid molecule. It is commonly used in pharmaceutical research and is known for its potential anti-inflammatory and analgesic properties. 3-(2,5-DIOXO-PYRROLIDIN-1-YL)-BENZOIC ACID has been studied for its potential in treating various diseases and disorders, including autoimmune conditions and chronic pain. It is also used as a building block in organic synthesis and has various industrial applications. The chemical structure of 3-(2,5-dioxo-pyrrolidin-1-yl)-benzoic acid makes it a valuable compound for medicinal and chemical research.

InChI:InChI=1/C11H9NO4/c13-9-4-5-10(14)12(9)8-3-1-2-7(6-8)11(15)16/h1-3,6H,4-5H2,(H,15,16)

Upstream product

• 110-15-6 succinic acid 
• 99-05-8 meta-aminobenzoic acid 
• 108-30-5 succinic acid anhydride 

Downstream Products

• 259222-20-3 3-(3-carboxypropanamido)benzoic acid 
• 110-15-6 succinic acid 
• 99-05-8 meta-aminobenzoic acid 
• 123-25-1 succinic acid diethyl ester 

Relevant articles and documents

Multitargeted Compounds Derived from (2,5-Dioxopyrrolidin-1-yl)(phenyl)-Acetamides as Candidates for Effective Anticonvulsant and Antinociceptive Agents

We developed a focused set of original hybrid pyrrolidine-2,5-dione derivatives with potent anticonvulsant and antinociceptive properties. These hybrid compounds demonstrated broad-spectrum protective activity in a range of mouse models, such as the maximal electroshock (MES) test, the pentylenetetrazole-induced seizures (scPTZ), and the 6 Hz (32 mA) seizures. Compound 22 showed the most potent anticonvulsant activity (ED50 MES = 23.7 mg/kg, ED50 6 Hz (32 mA) = 22.4 mg/kg, ED50 scPTZ = 59.4 mg/kg). In addition, 22 revealed potent efficacy in the formalin-induced tonic pain. These in vivo activities of 22 are likely mediated by several targets and may result from the inhibition of central sodium/calcium currents and transient receptor potential vanilloid 1 (TRPV1) receptor antagonism. Finally, the lead compound 22 revealed drug-like absorption, distribution, metabolism, excretion, toxicity (ADME-Tox) properties in the in vitro assays, making it a potential candidate for further development in epilepsy and neuropathic pain indications.

Synthesis, anticholinesterase activity and structure-activity relationships of m-Aminobenzoic acid derivatives

The synthesis, acetylcholinesterase inhibitory capacity and structure-activity relationships of simple-structured m-Aminobenzoic acid derivatives are reported. Compound 1b was found to be more potent than galanthamine and tacrine in inhibiting acetylcholinesterase.