60755-87-5

Basic information

• Product Name: Canthin-6-one N-oxide
• Synonyms: Canthin-6-one N-oxide;Cathin-6-one 3-oxide
• CAS NO: 60755-87-5
• Molecular Formula: C14H8N2O2
• Molecular Weight: 236.22552
• Mol File: 60755-87-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Canthin-6-one N-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: Canthin-6-one N-oxide(60755-87-5)
• EPA Substance Registry System: Canthin-6-one N-oxide(60755-87-5)

Safety Data

• Hazardous Substances Data: 60755-87-5(Hazardous Substances Data)

Upstream product

• 479-43-6 canthin-6-one 
• 61-54-1 tryptamine 
• 50376-97-1 methyl 3-(4,9-dihydro-3H-pyrido[3,4-b]indol-1-yl)propanoate 
• 92256-33-2 N-(2-indol-3-yl-ethyl)-succinamic acid 
• 92870-51-4 N'-<3-(methoxycarbonyl)propanoyl>tryptamine 
• 91147-07-8 3-(9H-Pyrido<3,4-b>indol-1-yl)propansaeure-methylester 
• 18122-85-5 4,5-dihydro-canthin-6-one 
• 15741-79-4 N-benzyl tryptamine 
• 65284-99-3 N_b-benzyl-1,2,3,3a,4,5-hexahydrocanthin-6-one 
• 16979-93-4 N-benzylidene-2-(1H-indol-3-yl)ethylamine 
• 26400-25-9 1,2,3,3a,4,5-hexahydrocanthin-6-one 

Relevant articles and documents

Synthesis, in vitro antibacterial activities of a series of 3-N-substituted canthin-6-ones

An improved synthetic route of canthin-6-one was accomplished. To further enhance the antibacterial potency and improve water solubility, a series of 3-N-alkylated and 3-N-benzylated canthin-6-ones were designed and synthesized, and their in vitro antibacterial activities were evaluated. A clear structure-activity relationship with peak minimal inhibitory concentration (MIC) values of 0.98 (μg·mL-1) was investigated. Particularly, compounds 6i-r and 6t were found to be the most potent compounds with minimal inhibitory concentration (MIC) values lower than 1.95 (μg·mL-1) against Staphylococcus aureus.

USE OF CANTHIN-6-ONE AND ITS ANALOGS IN THE TREATMENT OF MYCOBACTERIA-LINKED PATHOLOGIES ( amended

The present invention relates to the use, for the preparation of a medicament intended for the treatment or the prevention of pathologies linked to, or caused by mycobacteria, of at least one of the compounds of the following formula (I): in which B represents in particular a nitrogen atom, and R1, R2, R3, R4, R5, R6, R7 and R8 represent in particular a hydrogen atom.