65284-99-3Relevant articles and documents
Cantffln - 6 - quaternary ammonium salt and its preparation method and application
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Paragraph 0033; 0036; 0037, (2017/12/02)
The invention relates to a canthium dicoccum-6-one quaternary ammonium salt and a preparation method and an application thereof. The structural formula of the compound is shown in a formula (1) in the specification, wherein R is ethyl, propyl, isopropyl, allyl, normal-butyl, isobutyl, normal-amyl, normal-octyl, unsubstituted benzyl or substituted benzyl substituted by a hydrogen atom, methyl, bromomethyl, trifluoromethyl, benzyloxyl, a fluorine atom or a chlorine atom; X is chlorine, bromine or iodine. The application is that of the compound for preparing antibacterial drugs.
An improved synthesis of canthin-6-one
Czerwinski, Kevin M.,Zificsak, Craig A.,Stevens, John,Oberbeck, Melissa,Randlett, Christopher,King, Melissa,Mennen, Steve
, p. 1225 - 1231 (2007/10/03)
An improved route has been devised which provides canthin-6-one in the highest yield from tryptamine to date. Tryptamine is converted to Nb-benzyltryptamine via reaction with benzoylchloride and reduction using LAH. Pictet-Spengler condensation with 2-ketoglutaric acid, removal of the protecting group by CTH, and aromatization with MnO2 affords canthin-6-one in 48% overall yield.
A New Synthesisof(+/-)Trypargine
Shimizu, Masato,Ishikawa, Masayuki,Komoda, Yasuo,Matsubara, Yukimi,Nakajima, Terumi
, p. 4529 - 4533 (2007/10/02)
A new route for the synthesis of (+/-)-trypargine (I) is described.The Pictet-Spengler reaction of Nb-benzyltryptamine with α-ketoglutaric acid was carried out in aprotic media to afford the key intermediate, 2-benzyl-1,2,3,3-tetrahydro-9H-pyri
