607723-66-0Relevant articles and documents
Synthesis and biological activity of novel substituted pyridines and purines containing 2,4-thiazolidinedione
Kim, Bok Young,Ahn, Joong Bok,Lee, Hong Woo,Kang, Sung Kwon,Lee, Jung Hwa,Shin, Jae Soo,Ahn, Soon Kil,Hong, Chung Il,Yoon, Seung Soo
, p. 433 - 447 (2007/10/03)
A series of substituted pyridines and purines containing 2,4-thiazolidinedione were designed and synthesized from their corresponding pyridines and purines. These synthesized compounds (entry no. 6a-d, 12a-e, 18a-d, 23a-c) were evaluated for their effect on triglyceride accumulation in 3T3-L1 cells in vitro and their hypoglycemic and hypolipidemic activity in the genetically diabetic KKAy mice in vivo. On the basis of their biological activities, 5-(4-{2-[N-methyl-(5-phenyl-pyridin-2-yl)amino]ethoxy} benzyl)thiazolidine-2,4-dione (6d) was selected as a candidate for further pharmacological studies.