6087-16-7

Basic information

• Product Name: 2-fluoro-3-methylpentanoic acid
• CAS NO: 6087-16-7
• Molecular Formula: C₆H₁₁FO₂
• Molecular Weight: 134.1487
• Mol File: 6087-16-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 201.1°C at 760 mmHg
• Flash Point: 75.4°C
• Density: 1.044g/cm³
• Vapor Pressure: 0.131mmHg at 25°C
• Refractive Index: 1.405
• CAS DataBase Reference: 2-fluoro-3-methylpentanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-fluoro-3-methylpentanoic acid(6087-16-7)
• EPA Substance Registry System: 2-fluoro-3-methylpentanoic acid(6087-16-7)

Safety Data

• Hazardous Substances Data: 6087-16-7(Hazardous Substances Data)

Usage

General Description

2-fluoro-3-methylpentanoic acid is a compound with the molecular formula C6H11FO2. It is an organic compound that contains a fluorine atom, a methyl group, and a pentanoic acid group. The presence of the fluorine atom makes it a fluoroalkanoic acid, and the methyl group is a substituent on the third carbon of the pentanoic acid chain. 2-fluoro-3-methylpentanoic acid has potential applications in pharmaceutical and chemical industries, as well as in research and development. Its specific properties and reactivity make it useful for various synthetic processes and in the creation of new compounds with specific properties. Studies may also be conducted to further understand its behavior and potential uses.

Upstream product

• 319-78-8 isoleucine 
• 18283-07-3 2-Ethoxycarbonimidoyl-2-fluoro-3-methyl-pentanoic acid ethyl ester 
• 129265-04-9 1-Methoxy-1-(phenylthio)-2-fluoro-3-methyl-1-pentene 
• 7309-45-7 ethyl 2-cyano-3-methylvalerate 
• 73-32-5 L-isoleucine 
• 73-32-5 L-isoleucine 

Downstream Products

• 136734-70-8 (2R,3S)-1-((2S,5S)-2,5-Dimethyl-pyrrolidin-1-yl)-2-fluoro-3-methyl-pentan-1-one 
• 136734-71-9 (2S,3S)-1-((2S,5S)-2,5-Dimethyl-pyrrolidin-1-yl)-2-fluoro-3-methyl-pentan-1-one 
• 132586-67-5 2-Fluoro-3-methyl-pentanoic acid 4-{5-[4-(2-fluoro-3-methyl-pentanoyloxy)-phenyl]-pyrimidin-2-yl}-phenyl ester 
• 136634-13-4 (2R,3S)-1-((2R,5R)-2,5-Dimethyl-pyrrolidin-1-yl)-2-fluoro-3-methyl-pentan-1-one 
• 136734-69-5 (2S,3S)-1-((2R,5R)-2,5-Dimethyl-pyrrolidin-1-yl)-2-fluoro-3-methyl-pentan-1-one 

Relevant articles and documents

An unusual conformation of α-haloamides due to cooperative binding with zincated porphyrins

CD and NMR spectroscopic evidence of cooperative binding between an α-halogen atom and a carboxamide group with a zinc porphyrin leads to an unprecedented conformation for the determination of the absolute stereochemistry of α-haloamides (α-halocarboxylic acids derivatized with 1,4-phenylenediamine) through the use of exciton-coupled circular dichroism (ECCD). With the use of chiral lactams, whose rotomeric contributions are minimized, both ECCD and NMR spectroscopy demonstrate that the porphyrin favors binding to the side of the sterically more demanding halogen atom as compared to the smaller hydrogen atom. In all, the data is strongly suggestive of an unusual conformation not observed before for α-chiral amides. A mnemonic for determining the absolute stereochemistry of α-halogenated carboxylic acids is provided.

THE TRANSFORMATION OF α-AMINOACIDS INTO FLUOROACIDS

The reactions of some α-aminoacids with excess sodium nitrite in polyhydrogen fluoride-pyridine are described.