609804-31-1Relevant articles and documents
1,3,5-Trisubstituted aryls as highly selective PPARδ agonists
Epple, Robert,Azimioara, Mihai,Russo, Ross,Bursulaya, Badry,Tian, Shin-Shay,Gerken, Andrea,Iskandar, Maya
, p. 2969 - 2973 (2007/10/03)
A series of highly potent and selective PPARδ agonists is described using the known non-selective ligand GW2433 as a structural template. Compound 1 is bioavailable, potent (10 nM), and shows no cross-activity with other PPAR subtypes up to 10 μM, making it a useful tool in studying the biological effects of selective PPARδ activation.
BENZOFURAN DERIVATIVE
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Page 150, (2008/06/13)
The present invention provides a benzofuran derivative of the formula [1]: wherein x is a group of the formula: -N="or" -CH=; Y is an optionally substituted amino group, an optionally substituted cycloalkyl group or an optionally substituted saturated heterocyclic group; A is a single bond, a carbon chain optionally having a double bond within or at the end(s) of the chain, or an oxygen atom; R1 is a hydrogen atom or a halogen atom; Ring B is an optionally substituted benzene ring; and R3 is a hydrogen atom, or a pharmaceutically acceptable salt thereof, which is useful as a medicament, especially as an activated blood coagulation factor X inhibitor.