870521-39-4Relevant articles and documents
1,3,5-Trisubstituted aryls as highly selective PPARδ agonists
Epple, Robert,Azimioara, Mihai,Russo, Ross,Bursulaya, Badry,Tian, Shin-Shay,Gerken, Andrea,Iskandar, Maya
, p. 2969 - 2973 (2007/10/03)
A series of highly potent and selective PPARδ agonists is described using the known non-selective ligand GW2433 as a structural template. Compound 1 is bioavailable, potent (10 nM), and shows no cross-activity with other PPAR subtypes up to 10 μM, making it a useful tool in studying the biological effects of selective PPARδ activation.