6110-83-4Relevant articles and documents
Formal total synthesis of (-)-emetine using catalytic asymmetric allylation of cyclic imines as a key step
Itoh, Takashi,Miyazaki, Michiko,Fukuoka, Hiromi,Nagata, Kazuhiro,Ohsawa, Akio
, p. 1295 - 1297 (2007/10/03)
Catalytic asymmetric allylation of 3,4-dihydro-6,7-dimethoxyisoquinoline was carried out using allyltrimethoxysilane in the presence of Cu(I) and tol-BINAP. The allyl adduct thus obtained was transformed to a chiral synthetic intermediate for (-)-emetine in good yield. The procedure was applied to the total synthesis of ent-emetine.