61367-10-0 Usage
Description
1-(2-chloroethyl)-3-[4-(hydroxymethyl)cyclohexyl]urea is a chemical compound with potential therapeutic and pharmaceutical applications. It is a urea derivative featuring a chloroethyl and hydroxymethyl substituent on the cyclohexyl ring. 1-(2-chloroethyl)-3-[4-(hydroxymethyl)cyclohexyl]urea may exhibit antitumor and cytotoxic properties, making it a potential candidate for cancer treatment. Additionally, it may also have applications in drug development and medicinal chemistry due to its structural features and potential biological activities. However, further research and evaluation are necessary to fully understand the pharmacological potential and any potential side effects of this compound.
Uses
Used in Pharmaceutical Applications:
1-(2-chloroethyl)-3-[4-(hydroxymethyl)cyclohexyl]urea is used as a potential therapeutic agent for cancer treatment due to its antitumor and cytotoxic properties. It may be effective against various types of cancer, and its specific application would depend on the results of further research and clinical trials.
Used in Drug Development:
1-(2-chloroethyl)-3-[4-(hydroxymethyl)cyclohexyl]urea is used as a structural component in the development of new drugs. Its unique chemical features may contribute to the creation of novel pharmaceuticals with improved efficacy and reduced side effects.
Used in Medicinal Chemistry:
1-(2-chloroethyl)-3-[4-(hydroxymethyl)cyclohexyl]urea is used as a compound of interest in medicinal chemistry. Its potential biological activities and structural characteristics make it a valuable candidate for further study and development in the field of medicinal chemistry, with the aim of discovering new therapeutic agents and understanding their mechanisms of action.
Check Digit Verification of cas no
The CAS Registry Mumber 61367-10-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,1,3,6 and 7 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 61367-10:
(7*6)+(6*1)+(5*3)+(4*6)+(3*7)+(2*1)+(1*0)=110
110 % 10 = 0
So 61367-10-0 is a valid CAS Registry Number.
61367-10-0Relevant articles and documents
Synthesis of analogues of N (2 chloroethyl) N' trans 4 methylcyclohexyl) N nitrosourea for evaluation as anticancer agents
Johnston,McCaleb,Clayton,Frye,Krauth,Montgomery
, p. 279 - 290 (2007/10/04)
The superior activity of N (2 chloroethyl) N' (trans 4 methylcyclohexyl) N nitrosourea (MeCCNU) against advanced murine Lewis lung carcinoma in comparisons with the cis form and other nitrosoureas prompted the synthesis of a number of MeCCNU analogues, including several cis trans pairs. The methyl group was replaced by a variety of substituents (CO2H, CH2CO2H, CO2Me, CH2OAc, CH2Cl, OMe); the trans 3 methylcyclohexyl, cis 2 methyl 1,3 dithian 5 yl, cis and trans 2 methyl 1,3 dithian 5 yl tetraoxide, and 1 methylhexyl (open chain) analogues were also prepared. Preliminary tests against murine leukemia L1210 revealed therapeutic indices (ED50/LD10) ranging from 0.26 to 0.79; all but 3 analogues effected 50% cure rates at nontoxic doses, the open chain analogue being one of the least active. In terms of therapeutic index, diequatorial (trans 4) isomers were, with one exception, as active as or, in 4 of the 8 examples, somewhat more active than the corresponding axial equatorial (cis 4) isomers. In this series, 4 of the 5 2-fluoroethyl analogues prepared were clearly inferior to the corresponding 2 chloroethyl analogues.
