61436-88-2

Basic information

• Product Name: Benzamide,2-bromo-N-methyl-
• Synonyms: Benzamide,o-bromo-N-methyl- (7CI);2-Bromo-N-methylbenzamide;NSC 100665
• CAS NO: 61436-88-2
• Molecular Formula: C₈H₈BrNO
• Molecular Weight: 214.0592
• Product Categories: amine|alkyl bromide;blocks;Bromides;Carboxes
• Mol File: 61436-88-2.mol
• Article Data: 11

Chemical Properties

• Melting Point: 143-146
• Boiling Point: 319 °C at 760 mmHg
• Flash Point: 146.7 °C
• Appearance: /
• Density: 1.466 g/cm³
• Vapor Pressure: 0.000349mmHg at 25°C
• Refractive Index: 1.565
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Benzamide,2-bromo-N-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide,2-bromo-N-methyl-(61436-88-2)
• EPA Substance Registry System: Benzamide,2-bromo-N-methyl-(61436-88-2)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• Hazardous Substances Data: 61436-88-2(Hazardous Substances Data)

Usage

General Description

Benzamide, 2-bromo-N-methyl- is a chemical compound with the molecular formula C8H8BrNO that is commonly used in organic synthesis and pharmaceutical research. It is a brominated derivative of N-methylbenzamide, and is often utilized as an intermediate in the production of various pharmaceuticals and agrochemicals. Benzamide, 2-bromo-N-methyl- is known for its ability to react with a variety of other chemicals, making it a valuable tool in the development of new compounds and materials. Additionally, it has been studied for its potential biological activity and therapeutic applications, particularly in the field of cancer research.

InChI:InChI=1/C8H8BrNO/c1-10-8(11)6-4-2-3-5-7(6)9/h2-5H,1H3,(H,10,11)

Upstream product

• 122889-68-3 N-Acetyl-2-bromo-N-methyl-benzamide 
• 122889-69-4 N-methyl-N-propionyl-2-bromobenzamide 
• 122889-70-7 2-Bromo-N-methyl-N-phenylacetyl-benzamide 
• 74-89-5 methylamine 
• 88-65-3 2-bromobenzoic-acid 
• 593-51-1 methylamine hydrochloride 
• 7154-66-7 2-bromobenzoic acid chloride 
• 88070-48-8 N-methylbenzamide 

Downstream Products

• 66896-72-8 N-(2-Bromo-benzoyl)-N-methyl-benzenesulfonamide 
• 144175-28-0 2-Bromo-N-chloromethyl-N-methyl-benzamide 
• 698-19-1 N-methyl-2-bromobenzylamine 
• 7114-78-5 2,3-Dimethyl-1-oxo-1,2-dihydroisoquinoline 
• 816418-36-7 4,5-dimethyl-5H-phenanthridin-6-one 
• 833482-53-4 2-(4-fluorophenoxy)-N-methylbenzylamine 
• 144175-21-3 N-(diphenyloxophosphinyl)methyl-N-methyl-2-bromobenzamide 
• 7375-70-4 N⁽¹⁾,N⁽²⁾-bis(2-bromobenzyl)-N⁽¹⁾,N⁽²⁾-dimethylpropane-1,3-diamine 
• 123268-79-1 Methyl-bis-(2-trimethylsilanyl-benzyl)-amine 
• 550-44-7 N-methylphthalimide 
• 26597-63-7 3-hydroxy-2-methyl-3-phenyl-2,3-dihydro-isoindol-1-one 
• 835-18-7 3-phenyl-2,3-dihydro-isoindol-1-one 
• 2527-66-4 2-methyl-1,2-benzisothiazole-3(2H)-one 
• 34497-10-4 2-methyl-3-phenylisoquinolin-1(2H)-one 

Relevant articles and documents

Ni-Catalyzed Reductive Arylcyanation of Alkenes

We disclose a Ni-catalyzed reductive arylcyanation of alkene using environmentally benign and nontoxic organo cyanating reagent N-cyano-N-phenyl-p-toluenesulfonamide. This reaction provides a new method for the rapid synthesis of cyano-substituted oxindoles and isoquinoline-1,3-diones and features high functional group tolerance. In addition, an enantioselective version was developed for the construction of enantiomerically enriched 3-cyanomethyl oxindole. This method has also been applied to the synthesis of natural alkaloids (+)-esermethole and (+)-physostigmine.

COMPOUNDS AND USES THEREOF

The present invention features compounds useful in the treatment of neurological disorders. The compounds of the invention, alone or in combination with other pharmaceutically active agents, can be used for treating or preventing neurological disorders.

Nickel-catalyzed regioselective C-H halogenation of electron-deficient arenes

A straightforward Ni(ii)-catalyzed general strategy was developed for the ortho-halogenation of electron-deficient arenes with easily available halogenating reagents N-halosuccinimides (NXS; X = Br, Cl and I). The transformation was highly regioselective and a wide substrate scope and functional group tolerance were observed. This discovery could be of great significance for the selective halogenation of amides, benzoic esters and other substances with guiding groups. Mechanistic investigations were also described.