816418-36-7

Basic information

• Product Name: 6(5H)-Phenanthridinone,4,5-dimethyl-(9CI)
• Synonyms: 6(5H)-Phenanthridinone,4,5-dimethyl-(9CI)
• CAS NO: 816418-36-7
• Molecular Formula: C15H13NO
• Molecular Weight: 223.26982
• Product Categories: METHYL
• Mol File: 816418-36-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 58-59 °C(Solv: isopropyl ether (108-20-3))
• Boiling Point: 403.9±28.0 °C(Predicted)
• Appearance: /
• Density: 1.175±0.06 g/cm3(Predicted)
• PKA: 1.05±0.20(Predicted)
• CAS DataBase Reference: 6(5H)-Phenanthridinone,4,5-dimethyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 6(5H)-Phenanthridinone,4,5-dimethyl-(9CI)(816418-36-7)
• EPA Substance Registry System: 6(5H)-Phenanthridinone,4,5-dimethyl-(9CI)(816418-36-7)

Safety Data

• Hazardous Substances Data: 816418-36-7(Hazardous Substances Data)

Upstream product

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Relevant articles and documents

Synthesis and antibacterial activity of 5-methylphenanthridium derivatives as FtsZ inhibitors

5-Methylphenanthridium derivatives were designed, synthesized and evaluated for their in vitro antibacterial activity and cell division inhibitory activity against various Gram-positive and -negative bacteria. Among them, compounds 5A2, 5B1, 5B2, 5B3, 5C1 and 5C2 displayed the best on-target antibacterial activity with an MIC value of 4?μg/mL against B. subtilis ATCC9372 and S. pyogenes PS, showing over 2-fold better activity than sanguinarine. The SARs showed that the 5-methylphenanthridium derivatives with the alkyl side chains at the 2-postion, especially the straight alkyl side chains exerted better on-target antibacterial activity.

Syntheses of heteroycles via palladium-catalyzed C-H activation/cyclization of diazonium salts (Part III): Phenanthridin-6-(5H)-ones

A series of phenanthridin-6-(5H)-ones were synthesized through a palladium-catalyzed C-H activation/cyclization strategy using diazonium salts in good yields. The best conditions included Pd(OAc)2 as the catalyst, PPh3 as the ligand, toluene as the solvent, K2CO3 as the base and 60 oC as the optimal temperature.

Synthesis of 6-phenanthridinones and their heterocyclic analogues through palladium-catalyzed sequential aryl-aryl and N-aryl coupling

(Chemical Equation Presented) 6-Phenanthridinones and their heterocyclic analogues were synthesized through a one-pot procedure based on consecutive Pd-catalyzed aryl-aryl and N-aryl coupling from iodoarenes ortho-substituted by electron-releasing substituents and amides of o-bromoarene- and heteroarenecarboxylic acids.