61502-90-7

Basic information

• Product Name: (9H-Fluoren-9-yl)methyl (pyrrolidin-2-ylmethyl)carbamate hydrochloride
• Synonyms: (9H-Fluoren-9-yl)methyl (pyrrolidin-2-ylmethyl)carbamate hydrochloride;2-([1,1'-Biphenyl]-4-yl)acetaldehyde
• CAS NO: 61502-90-7
• Molecular Formula: C₁₄H₁₂O
• Molecular Weight: 358.86182
• Mol File: 61502-90-7.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 341.0±21.0 °C(Predicted)
• Appearance: /
• Density: 1.061±0.06 g/cm3(Predicted)
• CAS DataBase Reference: (9H-Fluoren-9-yl)methyl (pyrrolidin-2-ylmethyl)carbamate hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (9H-Fluoren-9-yl)methyl (pyrrolidin-2-ylmethyl)carbamate hydrochloride(61502-90-7)
• EPA Substance Registry System: (9H-Fluoren-9-yl)methyl (pyrrolidin-2-ylmethyl)carbamate hydrochloride(61502-90-7)

Safety Data

• Hazardous Substances Data: 61502-90-7(Hazardous Substances Data)

Usage

Description

(9H-Fluoren-9-yl)methyl (pyrrolidin-2-ylmethyl)carbamate hydrochloride is a chemical compound featuring a fluorene-based structure with a pyrrolidin-2-ylmethylcarbamate group. This hydrochloride salt form is frequently utilized in pharmaceutical research and development, and its unique structure and properties may contribute to potential applications in drug design and discovery.

Uses

Used in Pharmaceutical Research and Development:
(9H-Fluoren-9-yl)methyl (pyrrolidin-2-ylmethyl)carbamate hydrochloride is used as a compound in pharmaceutical research and development for its potential role in drug design and discovery. Its unique structure and properties are being studied for possible applications in creating new medications.
Used in Drug Design and Discovery:
In the field of drug design and discovery, (9H-Fluoren-9-yl)methyl (pyrrolidin-2-ylmethyl)carbamate hydrochloride is used as a structural component for the development of novel therapeutic agents. Ongoing research is focused on understanding its biological activities and potential therapeutic uses, which may lead to the creation of new medications in the future.

Upstream product

• 39889-69-5 biphenyl-4-yl-acetyl chloride 
• 2350-89-2 p-vinylbiphenyl 
• 264915-98-2 2-([1,1'-biphenyl]-4-yl)-N-methoxy-N-methylacetamide 
• 37729-18-3 2-(biphenyl-4-yl)ethanol 
• 59793-29-2 methyl 2-(1,1'-biphenyl-4-yl)acetate 
• 5728-52-9 (4-biphenylyl)acetic acid 
• 31603-77-7 4-biphenylacetonitrile 
• 1591-31-7 4-iodo-biphenyl 
• 92-52-4 biphenyl 
• 25789-56-4 ethyl 2-([1,1'-biphenyl]-4-yl)-2-hydroxyacetate 
• 14062-23-8 4-biphenylylacetic acid ethyl ester 
• 3218-36-8 4-Phenylbenzaldehyde 
• 1129550-73-7 C₁₅H₁₄O 
• 36099-26-0 2-([1,1′-biphenyl]-4-yl)oxirane 

Downstream Products

• 1072896-68-4 p-methoxyphenyl (9-2-(4-biphenyl)ethylamino-3,5,9-trideoxy-5-glycolamido-D-glycero-α-D-galacto-2-nonulopyranosylonic acid)-(2->6)-β-D-galactopyranoside 
• 1147752-20-2 8-[[1-([1,1'-biphenyl]-4-ylmethyl)-2-oxo-2-[(2-phenylethyl)amino]ethyl](phenylmethyl)amino]-8-oxo-octanoic acid ethyl ester 
• 1431696-10-4 (E)-4-(3-(phenylsulfonyl)allyl)-1,1'-biphenyl 
• 1431696-16-0 (E)-4-(3-(phenylsulfonyl)prop-1-en-1-yl)-1,1'-biphenyl 
• 220211-94-9 5-phenyl-1H-inden-2(3H)-one 
• 70090-71-0 4-(prop-2-yn-1-yl)-1,1'-biphenyl 
• 349407-14-3 N-methyl-N-phenyl-[1,1'-biphenyl]-4-carboxamide 
• 149690-12-0 (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid ethyl ester hydrochloride 
• 31603-77-7 4-biphenylacetonitrile 

Relevant articles and documents

Trifluoromethanesulfonyl azide as a bifunctional reagent for metal-free azidotrifluoromethylation of unactivated alkenes

Vicinal trifluoromethyl azides have widespread applications in organic synthesis and drug development. However, their preparation is generally limited to transition-metal-catalyzed three-component reactions. We report here a simple and metal-free method that rapidly provides these building blocks from abundant alkenes and trifluoromethanesulfonyl azide (N3SO2CF3). This unprecedented two-component reaction employs readily available N3SO2CF3as a bifunctional reagent to concurrently incorporate both CF3and N3groups, which avoids the use of their expensive and low atom economic precursors. A wide range of functional groups, including bio-relevant heterocycles and amino acids, were tolerated. Application of this method was further demonstrated by scale-up synthesis (5 mmol), product derivatization to CF3-containing medicinal chemistry motifs, as well as late-stage modification of natural product and drug derivatives.

1-(1-Arylethylpiperidin-4-yl)thymine analogs as antimycobacterial TMPK inhibitors

A series of Mycobacterium tuberculosis TMPK (MtbTMPK) inhibitors based on a reported compound 3 were synthesized and evaluated for their capacity to inhibit MtbTMPK catalytic activity and the growth of a virulent M. tuberculosis strain (H37Rv). Modifications of the scaffold of 3 failed to afford substantial improvements in MtbTMPK inhibitory activity and antimycobacterial activity. Optimization of the substitution pattern of the D ring of 3 resulted in compound 21j with improved MtbTMPK inhibitory potency (three-fold) and H37Rv growth inhibitory activity (two-fold). Moving the 3-chloro substituent of 21j to the para-position afforded isomer 21h, which, despite a 10-fold increase in IC50-value, displayed promising whole cell activity (minimum inhibitory concentration (MIC) = 12.5 μM).

Stereoselective Synthesis of Vinylboronates by Rh-Catalyzed Borylation of Stereoisomeric Mixtures

The stereoselective preparation of vinylboronates via rhodium-catalyzed borylation of E/Z mixtures of vinyl actetates is described, and this method was also extended to synthesis of vinyldiboronates. These transformations feature high functional group compatibility and mild reaction conditions. Control experiments support a mechanism that involved a Rh-catalyzed borylation-isomerization sequence. The isomerization of (Z)-vinylboronates to (E)-isomers was also demonstrated.