59793-29-2

Basic information

• Product Name: [1,1'-BIPHENYL]-4-ACETIC ACID METHYL ESTER
• Synonyms: [1,1'-BIPHENYL]-4-ACETIC ACID METHYL ESTER;4-biphenylylacetic acid methyl ester;Biphenyl-4-yl-acetic acid Methyl ester;methyl 2-([1,1'-biphenyl]-4-yl)acetate
• CAS NO: 59793-29-2
• Molecular Formula: C₁₅H₁₄O₂
• Molecular Weight: 226.27046
• Mol File: 59793-29-2.mol
• Article Data: 51

Chemical Properties

• Melting Point: 19-21 °C
• Boiling Point: 342.8°C at 760 mmHg
• Flash Point: 144.9°C
• Appearance: /
• Density: 1.09g/cm³
• Vapor Pressure: 7.33E-05mmHg at 25°C
• Refractive Index: 1.556
• CAS DataBase Reference: [1,1'-BIPHENYL]-4-ACETIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: [1,1'-BIPHENYL]-4-ACETIC ACID METHYL ESTER(59793-29-2)
• EPA Substance Registry System: [1,1'-BIPHENYL]-4-ACETIC ACID METHYL ESTER(59793-29-2)

Safety Data

• Hazardous Substances Data: 59793-29-2(Hazardous Substances Data)

Usage

General Description

[1,1'-BIPHENYL]-4-ACETIC ACID METHYL ESTER is a chemical compound with a molecular formula of C15H14O2. It is a methyl ester derivative of [1,1'-biphenyl]-4-acetic acid and is commonly used in the manufacturing of pharmaceuticals, fragrances, and organic synthesis. [1,1'-BIPHENYL]-4-ACETIC ACID METHYL ESTER is a colorless, transparent liquid with a slightly sweet odor and is insoluble in water. It is often used as an intermediate in the synthesis of various organic compounds and has applications in the production of perfumes, flavors, and pharmaceuticals. The chemical possesses various properties that make it suitable for use in a wide range of industries and applications.

InChI:InChI=1/C15H14O2/c1-17-15(16)11-12-7-9-14(10-8-12)13-5-3-2-4-6-13/h2-10H,11H2,1H3

Upstream product

• 186581-53-3 diazomethane 
• 5728-52-9 (4-biphenylyl)acetic acid 
• 124-38-9 carbon dioxide 
• 61221-46-3 1-p-biphenylyl-3-chloropropane 
• 41841-16-1 (4-bromo-phenyl)-acetic acid methyl ester 
• 98-80-6 phenylboronic acid 
• 147283-85-0 (4-Trifluoromethanesulfonyloxy-phenyl)-acetic acid methyl ester 
• 67-56-1 methanol 
• 92-91-1 biphenyl-4-acetaldehyde 
• 1878-68-8 2-(4-bromophenyl)-acetic acid 
• 31603-77-7 4-biphenylacetonitrile 
• 78733-60-5 4-(3-Hydroxypropyl)[1,1'-biphenyl] 
• 74-88-4 methyl iodide 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 63780-50-7 1,1-biphenyl-4-ylacetamide 
• 5728-52-9 (4-biphenylyl)acetic acid 
• 81770-34-5 2-(4-biphenylyl)-2-methylpropionic acid methyl ester 
• 94209-48-0 5-biphenyl-4-yl-5-ethyl-pyrimidine-2,4,6-trione 
• 77529-41-0 4-(4-biphenylyl)-3-hydroxy-3-pyrroline-2,5-dione 
• 84864-02-8 3-Biphenyl-4-yl-4-methoxy-pyrrole-2,5-dione 
• 84864-01-7 3-Biphenyl-4-yl-4-hydroxy-1-methyl-pyrrole-2,5-dione 
• 61502-90-7 4-Biphenylacetaldehyde 
• 1401354-91-3 C₃₀H₃₁NO₃ 
• 1401355-03-0 C₃₀H₃₁NO₃ 
• 1403365-74-1 (E)-methyl 1-([1,1'-biphenyl]-4-yl)-2-styrylcyclopropanecarboxylate 
• 1403365-77-4 (E)-methyl 1-(naphthalen-2-yl)-2-styrylcyclopropanecarboxylate 
• 1403365-87-6 methyl 1-([1,1'-biphenyl]-4-yl)-2-formylcyclopropanecarboxylate 
• 1403365-97-8 methyl 1-([1,1'-biphenyl]-4-yl)-2-((methylamino)methyl)cyclopropanecarboxylate hydrochloride 

Relevant articles and documents

Copper-Catalyzed Ullmann-Type Coupling and Decarboxylation Cascade of Arylhalides with Malonates to Access α-Aryl Esters

We have developed a high-efficiency and practical Cu-catalyzed cross-coupling to directly construct versatile α-aryl-esters by utilizing readily available aryl bromides (or chlorides) and malonates. These gram-scale approaches occur with turnovers of up to 1560 and are smoothly conducted by the usage of a low catalyst loading, a new available ligand, and a green solvent. A variety of functional groups are tolerated, and the application occurs with α-aryl-esters to access nonsteroidal anti-inflammatory drugs (NSAIDs) on the gram scale.

Preparation method of carboxylic ester compound

The invention relates to a preparation method of a carboxylic ester compound, which comprises the following steps: reacting carboxylic acid with methanol in air under the catalysis of nitrite to obtain an ester compound, the preparation method disclosed by the invention has the advantages of rich raw material sources, cheap and easily available catalyst, mild reaction conditions, simplicity and convenience in operation and the like, a series of fatty carboxylic acids can be modified with high yield, and particularly, the traditional esterification method is generally not suitable for esterification of drug molecules. By utilizing the method, a series of known drug molecules can be modified, so that a shortcut is provided for discovering new drug molecules.

B(C6F5)3-catalyzed O-H insertion reactions of diazoalkanes with phosphinic acids

A highly efficient base-, metal-, and oxidant-free catalytic O-H insertion reaction of diazoalkanes and phosphinic acids in the presence of B(C6F5)3has been developed. This powerful methodology provides a green approach towards the synthesis of a broad spectrum of α-phosphoryloxy carbonyl compounds with good to excellent yields (up to 99% yield). The protocol features the advantages of operational simplicity, high atom economy, practicality, easy scalability and environmental friendliness.