81770-34-5

Basic information

• Product Name: 2-(4-biphenylyl)-2-methylpropionic acid methyl ester
• CAS NO: 81770-34-5
• Molecular Weight: 254.329
• Mol File: 81770-34-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-(4-biphenylyl)-2-methylpropionic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-biphenylyl)-2-methylpropionic acid methyl ester(81770-34-5)
• EPA Substance Registry System: 2-(4-biphenylyl)-2-methylpropionic acid methyl ester(81770-34-5)

Safety Data

• Hazardous Substances Data: 81770-34-5(Hazardous Substances Data)

Usage

Molecular Class

2-(4-biphenylyl)-2-methylpropionic acid methyl ester belongs to the class of organic compounds known as biphenyls and derivatives.

Methyl Ester

It is a methyl ester of 2-(4-biphenylyl)-2-methylpropionic acid.

Synthetic Intermediate

It is used as a synthetic intermediate in the production of pharmaceuticals and agrochemicals.

Potential Applications

It has potential applications in the field of organic synthesis and materials science.

Unique Properties

It has unique structural and chemical properties.

Health Hazards

It may pose health hazards if not properly managed.

Upstream product

• 547-63-7 Methyl isobutyrate 
• 92-66-0 4-bromo-1,1'-biphenyl 
• 74647-99-7 Methyl 2-(4'-biphenylyl)propanoate 
• 74-88-4 methyl iodide 
• 59793-29-2 methyl 2-(1,1'-biphenyl-4-yl)acetate 

Downstream Products

• 48170-23-6 2-([1,1'-biphenyl]-4-yl)-2-methylpropanoic acid 
• 83493-87-2 C₁₆H₁₈O 
• 83364-29-8 C₁₈H₂₂⁽²⁾H₆ 
• 83364-30-1 C₁₈H₂₂⁽²⁾H₆ 

Relevant articles and documents

Br?nsted Acid-Catalyzed Intramolecular Hydroarylation of β-Benzylstyrenes

Using triphenylmethylium tetrakis(pentafluorophenyl)borate as a convenient Br?nsted acid precatalyst, β-(α,α-dimethylbenzyl)styrenes are shown to cyclize efficiently to afford a variety of new indanes that possess a benzylic quaternary center. The geminal dimethyl-containing quaternary center is proposed to be necessary to arm the substrate for cyclization through steric biasing.

An improved chemo-enzymatic synthesis of 1-β-O-acyl glucuronides: Highly chemoselective enzymatic removal of protecting groups from corresponding methyl acetyl derivatives

(Chemical Equation Presented) An improved and widely applicable chemo-enzymatic method for the synthesis of a series of 1-β-O-acyl glucuronides 5a-f has been developed from the corresponding methyl acetyl derivatives 3a-f, which were stereospecifically synthesized from cesium salts of carboxylic acids 1a-f and methyl 2,3,4-tri-O-acetyl-1-bromo-1-deoxy-α-D- glucopyranuronate (2). Chemoselectivity of lipase AS Amano (LAS) in the hydrolytic removal of O-acetyl groups of 3a-f to provide methyl esters 4a-f was influenced by the nature of their 1-β-O-acyl groups; high selectivity was evident only for 3b and 3f. Carboxylesterase from Streptomyces rochei (CSR), newly screened as an alternative to LAS, showed much greater chemoselectivity toward the O-acetyl groups than LAS; 3a, 3d, and 3e were chemoselectively hydrolyzed only by CSR. The combination of CSR with LAS yielded better results in the hydrolysis of 3c and 3f than did single usage of CSR. Final deprotection of the methyl ester groups of 4a-f to provide 5a-f was chemoselectively achieved by using lipase from Candida antarctica type B (CAL-B) as well as esterase from porcine liver (PLE), although CAL-B possessed higher chemoselectivity and catalytic efficiency than did PLE. CSR also exhibited high chemoselectivity in the synthesis of (S)-naproxen 1-β-O-acyl glucopyranoside (7) from its 2,3,4,6-tetra-O-acetyl derivative 6.