48170-23-6

Basic information

• Product Name: 2-(biphenyl-4-yl)-2-methylpropanoic acid
• CAS NO: 48170-23-6
• Molecular Formula: C₁₆H₁₆O₂
• Molecular Weight: 240.297
• Mol File: 48170-23-6.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 389.3°C at 760 mmHg
• Flash Point: 286.1°C
• Density: 1.112g/cm³
• Vapor Pressure: 9.29E-07mmHg at 25°C
• Refractive Index: 1.569
• CAS DataBase Reference: 2-(biphenyl-4-yl)-2-methylpropanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(biphenyl-4-yl)-2-methylpropanoic acid(48170-23-6)
• EPA Substance Registry System: 2-(biphenyl-4-yl)-2-methylpropanoic acid(48170-23-6)

Safety Data

• Hazardous Substances Data: 48170-23-6(Hazardous Substances Data)

Usage

General Description

2-(biphenyl-4-yl)-2-methylpropanoic acid is a chemical compound with the molecular formula C17H16O2. It is a type of benzoic acid derivative with a methyl group attached to the alpha carbon atom. 2-(biphenyl-4-yl)-2-methylpropanoic acid is commonly used in pharmaceuticals, particularly as a non-steroidal anti-inflammatory drug (NSAID) with potential analgesic and anti-inflammatory properties. It has been studied for its potential in the treatment of various inflammatory conditions, including arthritis and musculoskeletal pain. The presence of the biphenyl group makes this compound a potential target for drug design and development, and it may have applications in the treatment of other medical conditions as well.

Upstream product

• 72212-34-1 Methylether von 2-p-Biphenyl-2-propanol 
• 81770-34-5 2-(4-biphenylyl)-2-methylpropionic acid methyl ester 
• 92962-22-6 2-([1,1'-biphenyl]-4-yl)-2-methylpropanenitrile 
• 101184-73-0 2-(4-bromophenyl)-2-methylpropanenitrile 
• 98-80-6 phenylboronic acid 
• 59793-29-2 methyl 2-(1,1'-biphenyl-4-yl)acetate 
• 74647-99-7 Methyl 2-(4'-biphenylyl)propanoate 
• 74-83-9 methyl bromide 
• 6341-72-6 2-(4-biphenylyl)propanoic acid 

Downstream Products

• 1418028-00-8 6-phenyl-3,3-dimethylbenzofuran-2(3H)-one 

Relevant articles and documents

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Palladium(II)-Catalyzed C(sp2)-H Carbonylation of Sterically Hindered Amines with Carbon Monoxide

A palladium-catalyzed, amine-directed C(sp2)-H carbonylation of α,α-disubstituted benzylamine under 1 atm of CO for the facile synthesis of sterically hindered benzolactam has been developed. The key to success is the use of 2,2,6,6-tetramethyl-1-piperidinyloxy as the crucial sole oxidant. The synthetic utility of this transformation has been demonstrated by the first concise synthesis of the natural product spiropachysin-20-one.

Decarboxylative fluorination of aliphatic carboxylic acids via photoredox catalysis

The direct conversion of aliphatic carboxylic acids to the corresponding alkyl fluorides has been achieved via visible light-promoted photoredox catalysis. This operationally simple, redox-neutral fluorination method is amenable to a wide variety of carboxylic acids. Photon-induced oxidation of carboxylates leads to the formation of carboxyl radicals, which upon rapid CO2-extrusion and F? transfer from a fluorinating reagent yield the desired fluoroalkanes with high efficiency. Experimental evidence indicates that an oxidative quenching pathway is operable in this broadly applicable fluorination protocol.