63780-50-7

Basic information

• Product Name: [1,1'-Biphenyl]-4-acetamide
• CAS NO: 63780-50-7
• Molecular Formula: C14H13NO
• Molecular Weight: 211.263
• Mol File: 63780-50-7.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: [1,1'-Biphenyl]-4-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: [1,1'-Biphenyl]-4-acetamide(63780-50-7)
• EPA Substance Registry System: [1,1'-Biphenyl]-4-acetamide(63780-50-7)

Safety Data

• Hazardous Substances Data: 63780-50-7(Hazardous Substances Data)

Usage

General Description

The chemical [1,1'-Biphenyl]-4-acetamide, also known as N-phenyl-4-acetamide, is a white to light yellow crystalline powder with a molecular formula C14H13NO. It is a derivative of acetanilide, and it is commonly used as an intermediate in the synthesis of pharmaceuticals and organic compounds. [1,1'-Biphenyl]-4-acetamide has various applications in the production of dyes, pharmaceuticals, and other organic compounds. It is also used as a building block in the synthesis of various organic molecules. Additionally, [1,1'-Biphenyl]-4-acetamide has been studied for its potential biological and pharmacological properties, including its antipyretic and analgesic effects. However, as with any chemical, proper handling and safety precautions should be taken when working with [1,1'-Biphenyl]-4-acetamide.

Upstream product

• 39889-69-5 biphenyl-4-yl-acetyl chloride 
• 31603-77-7 4-biphenylacetonitrile 
• 57-13-6 urea 
• 156140-46-4 dimethyl (4-biphenyl)malonate 
• 591-50-4 iodobenzene 
• 98-80-6 phenylboronic acid 
• 1798-06-7 (4-iodophenyl)acetic acid 
• 1878-68-8 2-(4-bromophenyl)-acetic acid 
• 960-16-7 tributylphenylstannane 
• 934-56-5 trimethyl(phenyl)stannane 
• 92-91-1 biphenyl-4-acetaldehyde 
• 59793-29-2 methyl 2-(1,1'-biphenyl-4-yl)acetate 
• 5728-52-9 (4-biphenylyl)acetic acid 

Downstream Products

• 84864-02-8 3-Biphenyl-4-yl-4-methoxy-pyrrole-2,5-dione 
• 77529-41-0 4-(4-biphenylyl)-3-hydroxy-3-pyrroline-2,5-dione 
• 5728-52-9 (4-biphenylyl)acetic acid 

Relevant articles and documents

Merrifield MicroTube(TM) reactors for solid phase synthesis

Polystyrene grafted polypropylene MicroTube(TM) reactors (length x OD, 25 x 5 mm) have been functionalized with chloromethyl groups (Merrifield- type) using chloromethyl methyl ether and Lewis acid catalysts. A potentiometric method using a chloride ion selective electrode has been developed to measure the loading of the Merrifield MicroTube(TM) reactors. A typical loading of 25-35 μmol/tube for Merrifield MicroTube(TM) reactors has been achieved. Several reactions performed on Merrifield MicroTube(TM) reactors demonstrated that they are excellent supports for solid phase synthesis. As a result of the ease with which radiofrequency memory tags can be associated with and separated from the supports, these MicroTube(TM) reactors can facilitate the synthesis of combinatorial libraries.

Studies and synthesis of substituted 4-biphenyl acetamide derivatives

A new series of substituted 4-biphenylamides have been synthesized by condensation of 4-biphenyl acetic acid with different primary amines (aromatic and aliphatic). 4-Biphenyl acetic acid was first treated with thionyl chloride in dry benzene to prepare substituted 4-biphenyl acetyl chloride, which is then treated with different aliphatic or aromatic amines to synthesize various substituted 4-biphenyl acid-amide derivatives. The structure of newly synthesized compounds has been established by analytical and spectral methods. These synthesized compounds have shown antifungal properties against Fusarium udum and Curvularia lunata.

An improved synthesis of the selective matrix metalloproteinase inhibitor, Ro 28-2653

An efficient synthesis of Ro 28-2653, a selective matrix metalloproteinase inhibitor, has been developed. The title compound was prepared in four steps and 76% overall yield from 4-biphenylacetic acid. The key, barbituric acid formation step was significantly improved by using 2-propanol and potassium tert-butoxide as the solvent and base, respectively, instead of the typical ethanol and sodium ethoxide combination.