61532-32-9Relevant articles and documents
Microwave-Assisted C-2 Direct Alkenylation of Imidazo[4,5-b]pyridines: Access to Fluorescent Purine Isosteres with Remarkably Large Stokes Shifts
Baladi, Tom,Granzhan, Anton,Piguel, Sandrine
, p. 2421 - 2434 (2016/06/01)
We describe herein the first C-2 direct alkenylation of the valuable 3H-imidazo[4,5-b]pyridine promoted by microwave-assisted Pd/Cu co-catalysis. The reaction is rapid and compatible with a wide range of functional groups either on the imidazo[4,5-b]pyridine ring or on the styryl bromides thereby leading to the isolation of 23 compounds with moderate to good yields. The relevance of this method is demonstrated by its application to the synthesis of new cross-conjuguated push-pull 2-vinyl- and 2-alkynylimidazo[4,5-b]pyridines characterized by satisfactory fluorescence quantum yields and remarkable solvatofluorochromic properties.
Rapid construction of imidazopyridines from ortho-haloaminopyridines
Li, Chaomin,Chen, Lily,Steinhuebel, Dietrich,Goodman, Andrew
supporting information, p. 2708 - 2712 (2016/06/09)
A practical strategy for the preparation of imidazopyridine derivatives from ortho-haloaminopyridines utilizing a two-step C-N coupling/cyclization reaction sequence has been developed. This procedure provides rapid and efficient access to many medicinally interesting imidazopyridine compounds and related imidazopyrazine/purine heterocycles.
Ethoxymethylenemalonates and Malononitriles (EMM reagents) as formic acid equivalents: Synthesis of fused-imidazoles under neutral or mildly acidic con
Segelstein, Barb E.,Chenard, Bert L.,Macor, John E.,Post, Ronald J.
, p. 1897 - 1900 (2007/10/02)
The use of ethoxymethylenemalonates and malononitriles (EMM reagents) for the efficient synthesis of fused imidazoles and related compounds is describe.
