61595-99-1

Basic information

• Product Name: 1H-Pyrazole, 3,5-bis(4-bromophenyl)-4,5-dihydro-1-phenyl-
• Synonyms: F0712-0068
• CAS NO: 61595-99-1
• Molecular Formula: C21H16Br2N2
• Molecular Weight: 456.179
• Mol File: 61595-99-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1H-Pyrazole, 3,5-bis(4-bromophenyl)-4,5-dihydro-1-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole, 3,5-bis(4-bromophenyl)-4,5-dihydro-1-phenyl-(61595-99-1)
• EPA Substance Registry System: 1H-Pyrazole, 3,5-bis(4-bromophenyl)-4,5-dihydro-1-phenyl-(61595-99-1)

Safety Data

• Hazardous Substances Data: 61595-99-1(Hazardous Substances Data)

Upstream product

• 1122-91-4 4-bromo-benzaldehyde 
• 99-90-1 para-bromoacetophenone 
• 5471-96-5 1,3-bis(4-bromophenyl)-2-propen-1-one 
• 100-63-0 phenylhydrazine 
• 5471-96-5 (E)-1,3-bis(4-bromophenyl)prop-2-en-1-one 

Downstream Products

• 1174651-71-8 1-phenyl-3,5-di(4-trimethylsilylethynylphenyl)pyrazoline 

Relevant articles and documents

Synthesis and antimicrobial evaluation of arylated 1,3,5-triphenyl pyrazoline derivatives using suzuki-miyaura reactions

The first palladium –catalyzed coupling reactions of 1,3,5-triphenyl pyrazoline are reported. The Suzuki-Miyaura reaction of 3-(4-bromophenyl)-1,5-diphenyl pyrazoline with one equivalent of arylboronic acids afforded 3-(biphenyl)-1,5-diphenyl pyrazoline in 53-78 % yield. While the Suzuki-Miyaura reactions of 3,5-bis(4-bromophenyl)-1-phenyl pyrazoline with two equivalent of arylboronic acids gave 3,5-bis(biphenyl)-1-phenyl pyrazoline in 55-80% yield. The characterization of the synthesized derivatives (5a-h) and (6a-h) were accomplished on the basis of NMR, FT-IR, and mass techniques. The newly pyrazoline derivatives have been investigated for their in vitro antibacterial activity against gram- negative and gram-positive bacteria. The di-coupling compounds (6a-h) exhibited promising antibacterial against all four bacterial strains compared to the mono-coupling compounds (5a-h) which displayed a slight activity. The compound 6d showed a potent activity significantly more active than Trimethoprim (100μg/ml).

Iron-catalyzed aerobic oxidative aromatization of 1,3,5-trisubstituted pyrazolines

A simple and high yielding method for the synthesis of tri-substituted pyrazoles via iron(III) catalyzed aerobic oxidative aromatization of pyrazolines has been reported. The process demonstrates a variety of functional group tolerance.

Novel efficient green electroluminescent conjugated polymers based on fluorene and triarylpyrazoline for light-emitting diodes

A series of novel light-emitting conjugated polymers based on fluorene and triarylpyrazoline were synthesized in good yields through Suzuki coupling reactions. The resulting polymers were characterized by NMR, FT-IR, elemental analysis, DSC, TGA and GPC.