5471-96-5

Basic information

• Product Name: 1,3-BIS-(4-BROMO-PHENYL)-PROPENONE
• Synonyms: 1,3-BIS-(4-BROMO-PHENYL)-PROPENONE
• CAS NO: 5471-96-5
• Molecular Formula: C₁₅H₁₀Br₂O
• Molecular Weight: 366.05
• Mol File: 5471-96-5.mol
• Article Data: 55

Chemical Properties

• Boiling Point: 450.6°C at 760 mmHg
• Flash Point: 131.2°C
• Appearance: /
• Density: 1.647g/cm³
• Vapor Pressure: 2.6E-08mmHg at 25°C
• Refractive Index: 1.664
• CAS DataBase Reference: 1,3-BIS-(4-BROMO-PHENYL)-PROPENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-BIS-(4-BROMO-PHENYL)-PROPENONE(5471-96-5)
• EPA Substance Registry System: 1,3-BIS-(4-BROMO-PHENYL)-PROPENONE(5471-96-5)

Safety Data

• Hazardous Substances Data: 5471-96-5(Hazardous Substances Data)

Usage

General Description

1,3-BIS-(4-BROMO-PHENYL)-PROPENONE is a chemical compound with the molecular formula C15H11Br2O. It is also known as dibromobenzylideneacetone, and is commonly used as a precursor in the synthesis of various pharmaceutical and agrochemical compounds. This chemical is a yellow to brown crystalline solid, and is highly flammable. It is also considered to be harmful if swallowed or inhaled, and can cause skin and eye irritation. 1,3-BIS-(4-BROMO-PHENYL)-PROPENONE should be handled and stored with caution, and proper safety measures should be taken when working with this chemical.

InChI:InChI=1/C15H10Br2O/c16-13-6-1-11(2-7-13)3-10-15(18)12-4-8-14(17)9-5-12/h1-10H/b10-3+

Upstream product

• 99-90-1 para-bromoacetophenone 
• 1122-91-4 4-bromo-benzaldehyde 
• 99-73-0 para-bromophenacyl bromide 
• 5471-96-5 (E)-1,3-bis(4-bromophenyl)prop-2-en-1-one 
• 766-96-1 4-bromo-1-ethynylbenzene 
• 1777-57-7 p-bromobenzoylmethylenetriphenylphosphorane 

Downstream Products

• 5471-96-5 4,4'-dibromo-cis-chalcone 
• 100965-18-2 (2RS,3SR)-2,3-dibromo-1,3-bis-(4-bromo-phenyl)-propan-1-one 
• 100965-18-2 (2RS,3RS)-2,3-dibromo-1,3-bis-(4-bromo-phenyl)-propan-1-one 
• 61595-99-1 3-(4-bromophenyl)-5-(4-bromophenyl)-1-phenyl-2-pyrazoline 
• 494764-44-2 3,5-Bis-(4-bromo-phenyl)-4,5-dihydro-1H-pyrazole 
• 107553-45-7 2,4-Bis-(4-bromo-phenyl)-benzo[4,5]imidazo[1,2-a]pyrimidine 
• 204589-02-6 4,6-bis(4-bromophenyl)-2-methylpyrimidine 
• 399507-79-0 2,4,6-tris(4-bromophenyl)pyrimidine 
• 100965-18-2 1,3-bis(4-bromophenyl)-2,3-dibromopropanone 
• 55368-74-6 3,5-bis(4-bromophenyl)isoxazole 
• 33170-68-2 1,3-bis-(4-bromo-phenyl)-propane-1,3-dione 
• 204589-03-7 4,6-bis(4-cyanophenyl)-2-methylpyrimidine 

Relevant articles and documents

A π-Conjugated, Covalent Phosphinine Framework

Structural modularity of polymer frameworks is a key advantage of covalent organic polymers, however, only C, N, O, Si, and S have found their way into their building blocks so far. Here, the toolbox available to polymer and materials chemists is expanded

Chemoselective reduction of α,β-unsaturated carbonyl compounds in the presence of CuPd alloy nanoparticles decorated on mesoporous graphitic carbon nitride as highly efficient catalyst

Herein, we reported reductions of acid, amide, ester and ketone groups with selectivity (>99%) by the catalytic transfer hydrogenation of with CuPd alloy nanoparticles (NPs) decorated on mesoporous graphitic carbon nitride (Cu50Pd50/mpg-C3N4) catalyst under mild conditions in a water/methanol mixture. CuPd alloy NPs were synthesized by the co-reduction of palladium (II) acetylacetonate and copper(II) acetylacetonate in oleylamine (OAm) solution by the reduction of morpholine-borane solution and then assembled on mpg-C3N4 via liquid phase self‐assembly method. The α, β-unsaturated carbonyl compounds were obtained from the condensation reaction of the benzaldehyde derivatives with acetone derivatives. Cu50Pd50/mpg-C3N4 nanocatalyst was characterized by TEM, XRD, XPS, BET and ICP‐MS. Cu50Pd50/mpg-C3N4 nanocatalyst is highly active catalyst for the reduction of various organic groups and converted to high yield and 99% selectivity. The superior Cu50Pd50/mpg-C3N4 nanocatalyst is highly efficient and reusable catalyst which is reuse after 5 cycle with 98% conversion.

Design, synthesis, and SAR study of novel 4,5-dihydropyrazole-Thiazole derivatives with anti-inflammatory activities for the treatment of sepsis

Systemic inflammatory response syndrome is a major feature of sepsis which is one of the major causes of death worldwide. It has been reported that 3,5-diaryl-4,5-dihydropyrazole and thiazole derivatives have many biological functions, especially in the aspect of anti-inflammation. According to the strategy of pharmacophore combination, we introduced thiazole moiety into dihydropyrazole skeleton to design and synthesize a novel series of 2-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)-4-methylthiazole derivatives, and evaluated their anti-inflammatory activities for sepsis treatment. Preliminary structure?activity relationship (SAR) analysis was conducted by their inhibitory activities against nitric oxide (NO) release in LPS-induced RAW264.7 cells, and the optimal compound E26 exhibited more potent anti-inflammatory activity than the positive control treatment indomethacin and dexamethasone. In further mechanism study, our results showed that compound E26 significantly suppressed the production of interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), NO and inhibited the expressions of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) through blocking MAPKs signaling pathway. In addition, in vivo administration of compound E26 resulted in a significant improvement of LPS-induced sepsis in C57BL/6J mice, with reducing toxicity in multiple organs. Taken together, this study demonstrated the compound E26 could be a promising agent for the treatment of sepsis.

Synthesis and antimicrobial evaluation of arylated 1,3,5-triphenyl pyrazoline derivatives using suzuki-miyaura reactions

The first palladium –catalyzed coupling reactions of 1,3,5-triphenyl pyrazoline are reported. The Suzuki-Miyaura reaction of 3-(4-bromophenyl)-1,5-diphenyl pyrazoline with one equivalent of arylboronic acids afforded 3-(biphenyl)-1,5-diphenyl pyrazoline in 53-78 % yield. While the Suzuki-Miyaura reactions of 3,5-bis(4-bromophenyl)-1-phenyl pyrazoline with two equivalent of arylboronic acids gave 3,5-bis(biphenyl)-1-phenyl pyrazoline in 55-80% yield. The characterization of the synthesized derivatives (5a-h) and (6a-h) were accomplished on the basis of NMR, FT-IR, and mass techniques. The newly pyrazoline derivatives have been investigated for their in vitro antibacterial activity against gram- negative and gram-positive bacteria. The di-coupling compounds (6a-h) exhibited promising antibacterial against all four bacterial strains compared to the mono-coupling compounds (5a-h) which displayed a slight activity. The compound 6d showed a potent activity significantly more active than Trimethoprim (100μg/ml).