618902-06-0Relevant articles and documents
Synthesis and structure-activity relationships of 1-arylmethyl-3-(1-methyl-2-amino)ethyl-5-aryl-6-methyluracils as antagonists of the human GnRH receptor
Tucci, Fabio C.,Zhu, Yun-Fei,Guo, Zhiqiang,Gross, Timothy D.,Connors Jr., Patrick J.,Struthers, R. Scott,Reinhart, Greg J.,Saunders, John,Chen, Chen
, p. 3317 - 3322 (2007/10/03)
A new class of small molecule GnRH antagonists, the 1-arylmethyl-3-(1-methyl-2-amino)ethyl-5-aryl-6-methyluracils, was designed and a novel stereoselective synthesis for these compounds was developed. The stereochemical integrities of key intermediates (S