61995-11-7

Basic information

• Product Name: Phenol, 5-amino-2-methyl-, acetate (ester)
• CAS NO: 61995-11-7
• Molecular Formula: C9H11NO2
• Molecular Weight: 165.192
• Mol File: 61995-11-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Phenol, 5-amino-2-methyl-, acetate (ester)(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 5-amino-2-methyl-, acetate (ester)(61995-11-7)
• EPA Substance Registry System: Phenol, 5-amino-2-methyl-, acetate (ester)(61995-11-7)

Safety Data

• Hazardous Substances Data: 61995-11-7(Hazardous Substances Data)

Upstream product

• 5428-54-6 2-methyl-5-nitrophenol 
• 99-55-8 2-methyl-5-nitroaniline 

Downstream Products

• 782432-65-9 4-(3-acetoxy-4-methylanilino)-7-benzyloxy-6-methoxyquinoline 
• 719298-94-9 Acetic acid 5-((E)-2-cyano-vinylamino)-4-iodo-2-methyl-phenyl ester 
• 719299-15-7 6-hydroxy-5-methyl-1H-indole-3-carbonitrile 

Relevant articles and documents

Synthesis, molecular modeling, and evaluation of nonphenolic indole analogs of mycophenolic acid

Based on the promising activity of an indole-3-carboxamide derivative, a nonphenolic analog of mycophenolic acid (MPA), we report herein the synthesis of a compound containing two important features for the activity of MPA, the ring methoxy and methyl. The synthesis was accomplished using two strategies; a method dependent on stepwise building of the hexenoate side chain followed by the indolecarboxamide ring system, and a convergent route that depended on 1,3-sigmatropic rearrangement as a key step. Docking experiments on both Chinese Hamster and Human Type-II inosine monophosphate dehydrogenase (IMPDH) showed that this compound has potential binding interactions with the NAD site. The analogs showed no activity against MCF7-S, MCF7-R, or IGR-OV1 cancer cells.

4-ANILINOQUINAZOLINE DERIVATIVES

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