62001-29-0Relevant articles and documents
Design, synthesis, and biological evaluation of novel 4,4-difluoro-1-methyl-N, 6-diphenyl-5, 6-dihydro-4H-pyrimido [4, 5-b] [1, 2, 4] triazolo [4, 3-d] [1, 4] diazepin-8-amine derivatives as potential BRD4 inhibitors
Li, Jiuhui,Zhang, Wenjie,Qiu, Qianqian,Zhou, Daoguang,Feng, Ziying,Tong, Zhenzhen,Wei, Jiaxin,Huang, Wenlong,Li, Jieming,Qian, Hai,Shi, Wei
, p. 1117 - 1128 (2021)
Bromodomain-containing protein 4 (BRD4) plays an extremely important physiological role in cancer, and the BRD4 inhibitors can effectively inhibit the proliferation of tumor cells. By taking BI-2536 (PLK1 and BRD4 inhibitor) as the lead compound, sixteen
RSK2 benzo triazole derivatives as inhibitors of synthesis and use
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Paragraph 0075-0077, (2016/10/07)
The invention relates to synthesis of a benzotriazol derivative and its application, specifically to a compound as shown in the following formula II, a pharmaceutical composition containing the compound as shown in the formula II and an application of the compound in preparation of drugs for treating or preventing RSK2-mediated diseases.
Simple and convenient preparation of 1-(arylamino)methylbenzotriazoles and -(arylamino)methylbenzimidazoles
Milata,Kada,Zalibera,Belicova
, p. 215 - 220 (2007/10/03)
The preparation of 1-(arylamino)methylbenzotriazoles 1a-17a and benzimidazoles 1b-17b is described and their antibacterial activity evaluated. 1-Hydroxymethylbenzazoles react with the appropriate aniline to yield the target compounds. These were characterized using 1H NMR, IR, UV spectra. The compounds displayed no significant antibacterial activity.