62155-72-0Relevant articles and documents
Diastereoselective hydrogenation of α,β-unsaturated but-2-enamides to access the chiral 3-(p-tolyl) butanoic acids
Jiménez, Jacqueline,López, Mildred,Carranza, Vladimir,Mendoza, Angel,Varela, Jenaro,Sansinenea, Estibaliz,Ortiz, Aurelio
, p. 235 - 239 (2016/12/28)
An alternative methodology for the synthesis of chiral 3-(p-tolyl) butanoic acids is presented. This was accomplished through the diastereoselective hydrogenation reaction of different chiral N-3-(p-tolyl) but-2-enamides, using Pd/C in EtOH, to produce the corresponding chiral N-3-(p-tolyl) butanamides with high chemical yields and moderate diastereomeric ratios. Removal of the chiral auxiliary from N-3-(p-tolyl) butanamides gave the respective enantiomerically pure acids.