622-08-2Relevant articles and documents
Highly selective reductive catalytic fractionation at atmospheric pressure without hydrogen
Ren, Tianyu,You, Shengping,Zhang, Zhaofeng,Wang, Yuefei,Qi, Wei,Su, Rongxin,He, Zhimin
supporting information, p. 1648 - 1657 (2021/03/09)
Reductive catalytic fractionation (RCF) is an efficient and selective way to produce phenolic monomers from lignin. However, this strategy is difficult to scale up due to its high operating pressure. In this work, we investigated RCF reaction at or near atmospheric pressure and without the use of hydrogen. The atmospheric RCF (ARCF) was conducted in acidified ethylene glycol in glass vessels at 185-195 °C catalyzed by 5% Ru/C. The products mainly include propylguaiacol and propylsyringyl (up to 95.6% among the lignin monomers) and do not contain propanolguaiacol, propanolsyringyl, or H monomers. Although the total yield of lignin monomers in ARCF is about one-quarter less than that of RCF, the operation of ARCF is much easier, milder, safer, and cheaper due to the atmospheric condition and the feasibility of the semi-continuous operation.
4-Acyl Pyrrole Capped HDAC Inhibitors: A New Scaffold for Hybrid Inhibitors of BET Proteins and Histone Deacetylases as Antileukemia Drug Leads
Ahlert, Heinz,Bhatia, Sanil,Borkhardt, Arndt,Breit, Bernhard,Gunther, Stefan,Hansen, Finn K.,Hugle, Martin,Kraft, Fabian B.,Mishra, Pankaj,Schaker-Hubner, Linda,Schliehe-Diecks, Julian,Scholer, Andrea,Warstat, Robin
, p. 14620 - 14646 (2021/10/20)
Multitarget drugs are an emerging alternative to combination therapies. In three iterative cycles of design, synthesis, and biological evaluation, we developed a novel type of potent hybrid inhibitors of bromodomain, and extra-terminal (BET) proteins and histone deacetylases (HDACs) based on the BET inhibitor XD14 and well-established HDAC inhibitors. The most promising new hybrids, 49 and 61, displayed submicromolar inhibitory activity against HDAC1-3 and 6, and BRD4(1), and possess potent antileukemia activity. 49 induced apoptosis more effectively than the combination of ricolinostat and birabresib (1:1). The most balanced dual inhibitor, 61, induced significantly more apoptosis than the related control compounds 62 (no BRD4(1) affinity) and 63 (no HDAC inhibition) as well as the 1:1 combination of both. Additionally, 61 was well tolerated in an in vivo zebrafish toxicity model. Overall, our data suggest an advantage of dual HDAC/BET inhibitors over the combination of two single targeted compounds.
Composition for controlling pine wood nematode containing benzyloxyalcohol
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Paragraph 0055-0056, (2021/06/15)
The present invention relates to a composition for controlling pine nematode comprising a benzyloxyalcohol compound and a method for controlling pine nematode using the same.