62203-32-1

Basic information

• Product Name: (2-phenyl-4,5-dihydro-1,3-oxazole-4,4-diyl)dimethanol
• Synonyms: (2-Phenyl-4,5-dihydro-1,3-oxazole-4,4-diyl)dimethanol; 4,4(5H)-Oxazoledimethanol, 2-phenyl-; 4,4-bis(hydroxymethyl)-2-phenyl-2-oxazoline
• CAS NO: 62203-32-1
• Molecular Formula: C₁₁H₁₃NO₃
• Molecular Weight: 207.2258
• Mol File: 62203-32-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 393.2°C at 760 mmHg
• Flash Point: 191.6°C
• Density: 1.26g/cm³
• Vapor Pressure: 6.88E-07mmHg at 25°C
• Refractive Index: 1.584
• CAS DataBase Reference: (2-phenyl-4,5-dihydro-1,3-oxazole-4,4-diyl)dimethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (2-phenyl-4,5-dihydro-1,3-oxazole-4,4-diyl)dimethanol(62203-32-1)
• EPA Substance Registry System: (2-phenyl-4,5-dihydro-1,3-oxazole-4,4-diyl)dimethanol(62203-32-1)

Safety Data

• Hazardous Substances Data: 62203-32-1(Hazardous Substances Data)

Usage

General Description

(2-phenyl-4,5-dihydro-1,3-oxazole-4,4-diyl)dimethanol, also known as PDM, is a chemical compound that belongs to the class of diol-based diacids. It is a flexible building block that is used in the synthesis of various polymers, including polyester resins, polyurethanes, and epoxy resins. PDM has a unique molecular structure with two hydroxyl groups and an oxazole ring, making it useful for the production of high-performance materials with good mechanical properties and chemical resistance. It is commonly used in the manufacturing of coatings, adhesives, and composites, as well as in the pharmaceutical industry for the synthesis of new drugs and drug delivery systems. With its versatile applications, PDM plays a crucial role in the development of advanced materials for various industrial and biomedical purposes.

Upstream product

• 65-85-0 benzoic acid 
• 77-86-1 2-amino-2-hydroxymethyl-1,3-propanediol 

Downstream Products

• 100956-81-8 4,4-bis-acetoxymethyl-2-phenyl-4,5-dihydro-oxazole 
• 889893-47-4 (R)-4-hydroxymethyl-2-phenyl-4,5-dihydrooxazol-4-ylmethyl acetate 
• 889893-57-6 methyl (S)-2-benzoyloxymethyl-5-oxopyrrolidine-2-carboxylate 
• 889893-50-9 ethyl (S,E)-3-(4-hydroxymethyl-2-phenyl-4,5-dihydrooxazol-4-yl)acrylate 
• 889893-51-0 ethyl (S)-3-(4-hydroxymethyl-2-phenyl-4,5-dihydrooxazol-4-yl)propionate 
• 889893-58-7 ethyl (R)-3-(4-hydroxymethyl-2-phenyl-4,5-dihydrooxazol-4-yl)propionate 
• 889893-56-5 methyl (S)-4-(2-ethoxycarbonylethyl)-2-phenyl-4,5-dihydrooxazole-4-carboxylate 
• 889893-53-2 (S)-(-)-(4-(tert-butyldimethylsilyloxymethyl)-2-phenyl-4,5-dihydrooxazol-4-yl)methanol 
• 889893-49-6 ethyl (R,E)-3-(4-acetoxymethyl-2-phenyl-4,5-dihydrooxazol-4-yl)acrylate 
• 889893-52-1 (R)-4-(tert-butyldimethylsiloxymethyl)-2-phenyl-4,5-dihydrooxazol-4-ylmethyl acetate 
• 889893-55-4 ethyl (S)-3-[4-(tert-butyldimethylsiloxymethyl)-2-phenyl-4,5-dihydrooxazol-4-yl]-propionate 
• 889893-54-3 ethyl (S,E)-3-[4-(tert-butyldimethylsiloxymethyl)-2-phenyl-4,5-dihydrooxazol-4-yl]acrylate 

Relevant articles and documents

Solvent-Free Microwave-Assisted Efficient Synthesis of 4,4-Disubstituted 2-Oxazolines

4,4-Disubstituted 2-oxazolines have been synthesized by a microwave-promoted solvent-free direct condensation of carboxylic acids and disubstituted β-amino alcohols in good to excellent yields. Zinc oxide is a very good solid support in cases where a Lewis acid is required. The method described herein is a very good, safe, clean, economical, and environmentally friendly alternative to the classical procedures. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.

A SIMPLE SYNTHESIS OF Δ2-OXAZOLINES, Δ2-OXAZINES, Δ2-THIAZOLINES AND Δ2-IMIDAZOLINES

Carboxylic acids react with amino alcohols, amino mercaptans or diamines in the presence of triphenylphosphine, CCl4 and tert. bases to afford in 50-75percent yield the corresponding Δ2-oxazolines, Δ2-oxazines, Δ2-thiazolines and Δ2-imidazolines.