622405-78-1 Usage
Description
MPEG3-NHS, also known as m-PEG4-NHS ester, is a PEG (polyethylene glycol) linker that contains an NHS (N-hydroxysuccinimide) ester. This NHS ester can be utilized to label primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The hydrophilic PEG spacer enhances solubility in aqueous media, making MPEG3-NHS a versatile tool in various applications.
Uses
Used in Bioconjugation:
MPEG3-NHS is used as a bioconjugation agent for the modification of primary amines. The NHS ester reacts with the amine groups, forming stable amide bonds, which can be employed to attach functional groups or labels to proteins, oligonucleotides, and other amine-containing molecules.
Used in Drug Delivery Systems:
In the pharmaceutical industry, MPEG3-NHS is used as a component in the development of drug delivery systems. The PEG spacer can improve the solubility and bioavailability of drugs, while the NHS ester allows for the covalent attachment of drug molecules to carriers or targeting ligands.
Used in Diagnostics:
MPEG3-NHS is used as a labeling agent in the development of diagnostic tools. The NHS ester can be employed to attach detection molecules, such as fluorescent dyes or radioisotopes, to biomolecules for various imaging and detection techniques.
Used in Research and Development:
In the field of research, MPEG3-NHS is used as a versatile reagent for the modification of amine-containing molecules. This allows scientists to study the effects of PEGylation on the properties of these molecules, such as stability, solubility, and biological activity.
Used in Protein Engineering:
In protein engineering, MPEG3-NHS is used as a tool for the site-specific modification of proteins. The NHS ester can be employed to introduce specific functional groups or labels at desired locations within a protein, enabling the study of protein structure, function, and interactions.
Used in Oligonucleotide Synthesis:
In the synthesis of amine-modified oligonucleotides, MPEG3-NHS is used as a coupling agent. The NHS ester can be employed to attach various functional groups, such as fluorescent dyes or affinity tags, to the oligonucleotides, enhancing their utility in molecular biology applications.
Check Digit Verification of cas no
The CAS Registry Mumber 622405-78-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,2,2,4,0 and 5 respectively; the second part has 2 digits, 7 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 622405-78:
(8*6)+(7*2)+(6*2)+(5*4)+(4*0)+(3*5)+(2*7)+(1*8)=131
131 % 10 = 1
So 622405-78-1 is a valid CAS Registry Number.
622405-78-1Relevant articles and documents
Polyethylene glycol monomethyl ether statin compound and preparation method thereof
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Paragraph 0018, (2018/04/21)
The invention relates to a polyethylene glycol monomethyl ether statin compound and a preparation method thereof. The method mainly comprises the following steps: 1) activating an end group of polyethylene glycol monomethyl ether; and 2) connecting the activated polyethylene glycol monomethyl ether statin compound by amino acid or oligopeptide to obtain the polyethylene glycol monomethyl ether statin compound. The polyethylene glycol monomethyl ether statin compound has a structure: mPEG-(A)i-(statins)j, wherein mPEG is polyethylene glycol monomethyl ether and has a structure as shown in the specification, n is an integer ranging from 1 to 24, A is amino acid or oligopeptide, i is an integer ranging from 1 to 6, statins are statin compounds, and j is an integer ranging from 1 to 6. The load rate of a drug is increased by the statin compounds modified by polyethylene glycol. Due to the modification of polyethylene glycol, the absorption of the drum is improved, the acting time is prolonged, the curative effect is enhanced, and toxic or side effects are avoided.
