883554-11-8 Usage
Description
m-PEG4-t-butyl ester is a PEG (polyethylene glycol) linker that features a t-butyl ester group. m-PEG4-t-butyl ester is characterized by a t-butyl protected carboxyl group, which can be selectively deprotected under acidic conditions. The hydrophilic PEG spacer within the molecule enhances its solubility in aqueous media, making it a versatile component in various applications.
Uses
Used in Pharmaceutical Industry:
m-PEG4-t-butyl ester is used as a drug delivery agent for improving the solubility and bioavailability of therapeutic agents. The hydrophilic PEG spacer aids in the dispersion of hydrophobic drugs in aqueous environments, facilitating their absorption and distribution within the body.
Used in Chemical Synthesis:
In the field of chemical synthesis, m-PEG4-t-butyl ester serves as a protecting group for carboxyl functions. The t-butyl ester can be selectively removed under acidic conditions, allowing for the controlled deprotection and subsequent modification of the carboxyl group in multi-step synthesis processes.
Used in Bioconjugation:
m-PEG4-t-butyl ester is utilized as a bioconjugation agent to attach biologically active molecules, such as peptides, proteins, or nucleic acids, to other molecules or surfaces. The PEG spacer provides a hydrophilic environment that can reduce aggregation and increase stability, while the t-butyl ester group allows for selective deprotection and subsequent conjugation reactions.
Used in Material Science:
In material science, m-PEG4-t-butyl ester is employed as a component in the design of hydrogels, micelles, and other nanostructures. The PEG spacer contributes to the overall hydrophilicity and stability of these materials, while the t-butyl ester group can be used for further functionalization or cross-linking under controlled conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 883554-11-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,8,3,5,5 and 4 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 883554-11:
(8*8)+(7*8)+(6*3)+(5*5)+(4*5)+(3*4)+(2*1)+(1*1)=198
198 % 10 = 8
So 883554-11-8 is a valid CAS Registry Number.
883554-11-8Relevant articles and documents
Live-Cell Protein Modification by Boronate-Assisted Hydroxamic Acid Catalysis
Adamson, Christopher,Kajino, Hidetoshi,Kanai, Motomu,Kawashima, Shigehiro A.,Yamatsugu, Kenzo
supporting information, p. 14976 - 14980 (2021/09/29)
Selective methods for introducing protein post-translational modifications (PTMs) within living cells have proven valuable for interrogating their biological function. In contrast to enzymatic methods, abiotic catalysis should offer access to diverse and new-to-nature PTMs. Herein, we report the boronate-assisted hydroxamic acid (BAHA) catalyst system, which comprises a protein ligand, a hydroxamic acid Lewis base, and a diol moiety. In concert with a boronic acid-bearing acyl donor, our catalyst leverages a local molarity effect to promote acyl transfer to a target lysine residue. Our catalyst system employs micromolar reagent concentrations and affords minimal off-target protein reactivity. Critically, BAHA is resistant to glutathione, a metabolite which has hampered many efforts toward abiotic chemistry within living cells. To showcase this methodology, we installed a variety of acyl groups inE. colidihydrofolate reductase expressed within human cells. Our results further establish the well-known boronic acid-diol complexation as abona fidebio-orthogonal reaction with applications in chemical biology and in-cell catalysis.
METHOD OF SYNTHESIZING A SUBSTANTIALLY MONODISPERSED MIXTURE OF OLIGOMERS
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Page/Page column 4, (2011/06/10)
The present invention relates to methods of synthesizing oligomeric compounds, and more particularly, to methods of synthesizing oligomer compounds comprising polyethylene glycol moieties. The present invention provides improved methods for synthesizing oligomers comprising polyethylene glycol moieties. Methods according to embodiments of the present invention may utilize reaction conditions that are milder, efficacious than those taught by conventional methods.
