62374-23-6Relevant articles and documents
A process for preparing 1 - O - acetyl - 2, 3, 5 - three - O - benzoyl - β - D - ribofuranosyl method (by machine translation)
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Paragraph 0012; 0015; 0017; 0019, (2018/10/11)
A process for preparing 1 - O - acetyl - 2, 3, 5 - three - O - benzoyl - β - D - ribofuranosyl method, including: S1, benzoylated reaction: the adenosine with organic solvent and mixed acid, dropping benzoyl chloride reaction, filtering, the filter cake washed with organic solvent, the filtrate, concentrating and recovering organic solvent to dry, adding methanol stirring beating, filtering, to obtain the [...]; S2, acylation reaction: [...] with the cosolvent and acetic anhydride mixing, stirring solution cleaning, dropping of a catalytic amount of paratoluenesulfonic acid, thermal insulation reaction, filtering, spend solvent washing the filter cake, the filtrate, washing filtrate, dried anhydrous magnesium sulfate, filtered, concentrated under reduced pressure for recovering the solvent, to obtain crude, recrystallization, get. The invention not only avoids the use of pyridine malodorous materials, but also has the step is short, the operation is simple, low cost, environment-friendly, "three wastes" less amount and the like, suitable for industrial production. (by machine translation)
A novel method for the introduction of fluorine into the purine 2-position: Synthesis of 2-fluoroadenosine and a formal synthesis of the antileukemic drug fludarabine
Braendvang, Morten,Gundersen, Lise-Lotte
, p. 2993 - 2995 (2008/02/10)
A novel method for the introduction of fluorine in the purine 2-position is described and employed in the synthesis of a potential antimycobacterial compound. Also 2-fluoroadenosine has been synthesized for the first time from adenosine with perbenzoylated 2-nitroadenosine as a key intermediate. Mild reaction conditions are employed and few synthetic steps are required. The novel synthesis of fluoroadenosine can be regarded as a formal synthesis of the antileukemic drug fludarabine phosphate. Georg Thieme Verlag Stuttgart.
IMPROVED SYNTHESIS OF 2-SUBSTITUTED ADENOSINES
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Page/Page column 14, (2008/06/13)
Synthesis of 2-substituted adenosines of formula (I) using 2-nitro pentabenzoyl adenosine, or 2-nitro pentaacetyl adenosine, as intermediate is described: Formula (I) wherein R = C1-6 alkoxy (straight or branched), a phenoxy group (unsubstitute